(2-(1-diethylaminoacetoxy)pentyl)benzoic acid (2- methoxy- 4- (2- (4- nitrooxybutoxycarbonyl)vinyl))phenyl ester

a nitric oxide donor; structure in first source

Also Known As:

ZJM 289; ZJM-289; ZJM289

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Nitrates: 6625
  - (2-(1-diethylaminoacetoxy)pentyl)benzoic acid (2-methoxy-4-(2-(4-nitrooxybutoxycarbonyl)vinyl))phenyl ester: 2
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Cinnamates: 48
      - (2-(1-diethylaminoacetoxy)pentyl)benzoic acid (2-methoxy-4-(2-(4-nitrooxybutoxycarbonyl)vinyl))phenyl ester: 2
Inorganic Chemicals: 9
- Electrolytes: 16106
  - Ions: 7857
    - Anions: 3501
      - Nitrates: 6625
        (2-(1-diethylaminoacetoxy)pentyl)benzoic acid (2-methoxy-4-(2-(4-nitrooxybutoxycarbonyl)vinyl))phenyl ester: 2
- Nitrogen Compounds: 67
  - Nitric Acid: 155
    - Nitrates: 6625
      - (2-(1-diethylaminoacetoxy)pentyl)benzoic acid (2-methoxy-4-(2-(4-nitrooxybutoxycarbonyl)vinyl))phenyl ester: 2

Experts

1.	Ji, Hui: 2 articles (12/2012 - 03/2010)
2.	Lai, Yisheng: 1 article (12/2012)
3.	Li, Tingting: 1 article (12/2012)
4.	Peng, Sixun: 1 article (12/2012)
5.	Wang, Xiaoli: 1 article (12/2012)
6.	Wang, Xuliang: 1 article (12/2012)
7.	Xu, Jinyi: 1 article (12/2012)
8.	Zhang, Yihua: 1 article (12/2012)
9.	Zhao, Qian: 1 article (12/2012)
10.	Min, Zhen-Li: 1 article (03/2010)

Related Diseases

1.	Thrombosis (Thrombus) 12/07/2012 - "Collectively, the present study demonstrates that the two enantiomers are as potent as ZJM-289 in inhibition of platelet aggregation and thrombosis and in neuroprotection, and (S)-ZJM-289 shows somewhat better effects than (R)-ZJM-289 and ZJM-289 in a few cases. " 12/07/2012 - "It was observed that the two enantiomers appeared to be almost as effective as ZJM-289 in inhibiting platelet aggregation in vitro and thrombus formation in vivo. " 12/07/2012 - "These findings may provide new insights into the development of therapeutic agents like ZJM-289 for the intervention of thrombosis-related ischemic stroke." 12/07/2012 - "ZJM-289 is a potent racemic agent which inhibits both platelet aggregation and thrombosis superior to a known anti-ischemic stroke drug 3-n-butylphthalide (NBP). "
2.	Infarction (Infarctions) 03/01/2010 - "3. ZJM-289 reduced infarct volume and brain-water content in ischemic brains and promoted functional recovery. " 12/07/2012 - "Furthermore, it was found that oral administration of the enantiomers and ZJM-289 for three days significantly reduced the infarct size, brain water content and neurological deficit in rats after cerebral ischemia reperfusion. "
3.	Reperfusion Injury 03/01/2010 - "ZJM-289, a novel nitric oxide donor, alleviates the cerebral ischaemic-reperfusion injury in rats."
4.	Brain Ischemia (Cerebral Ischemia) 12/07/2012 - "Furthermore, it was found that oral administration of the enantiomers and ZJM-289 for three days significantly reduced the infarct size, brain water content and neurological deficit in rats after cerebral ischemia reperfusion. "
5.	Body Weight (Weight, Body) 03/01/2010 - "2. Adult male rats were randomly divided into four groups: (i) sham operated; (ii) I/R (ischaemia for 90 min and reperfusion for 24 h) treated with vehicle; (iii) I/R treated with 0.1 mmol/kg body weight ZJM-289; and (iv) I/R treated with 0.2 mmol/kg body weight ZJM-289. "

Related Drugs and Biologics

1.	(2-(1-diethylaminoacetoxy)pentyl)benzoic acid (2- methoxy- 4- (2- (4- nitrooxybutoxycarbonyl)vinyl))phenyl ester
2.	Nitric Oxide Donors
3.	3-n-butylphthalide (butylphthalide)
4.	salicylhydroxamic acid (SHAM)

Related Therapies and Procedures

1.	Oral Administration