5- amino- 7- (cyclohexylamino)- 1- ethyl- 6- fluoro- 4- oxo- 1,4- dihydroquinoline- 3- carboxylic acid

inhibits Foxo1 transactivation; inhibits mRNA levels of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase; structure in first source

Also Known As:

AS 1842856; AS-1842856; AS1842856

Networked: 19 relevant articles (3 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid: 19

Experts

1.	Unterman, Terry G: 2 articles (04/2016 - 12/2015)
2.	Chen, Yanlian: 1 article (12/2022)
3.	Huang, Junjiu: 1 article (12/2022)
4.	Jin, Heping: 1 article (12/2022)
5.	Liu, Haiying: 1 article (12/2022)
6.	Ren, Jian: 1 article (12/2022)
7.	Zhao, Yong: 1 article (12/2022)
8.	Al Batran, Rami: 1 article (01/2021)
9.	Altamimi, Tariq R: 1 article (01/2021)
10.	Dimaano, M Toni E: 1 article (01/2021)

Related Diseases

1.	Diabetic Cardiomyopathies 11/14/2023 - "Additionally, AS1842856 improved mitochondrial function indicated by increased mitochondrial membrane potential and adenosine triphosphate production and decreased mitochondrial reactive oxygen species production in isolated cardiomyocytes exposed to HG. Excessive FOXO1 activation during diabetes reduces STAT3 activation, with subsequent impairment of mitochondrial quality, ultimately promoting the development of diabetic cardiomyopathy."
2.	Wounds and Injuries (Trauma) 07/01/2018 - "We found that FOXO1-selective inhibitor AS1842856 improved blood flow recovery and capillary density in ischemic hindlimb, and rescued the delay of wound closure with a concomitant augmentation of mean perfusion rate in diabetic mice. "
3.	Muscular Atrophy (Muscle Atrophy) 11/10/2023 - "Overexpression of GADD45A induced apoptosis and cell cycle arrest of myoblasts in vitro, and it could be partially restored by the FOXO1 inhibitor AS1842856, which also slowed the muscle atrophy process with improved motor function and prolonged survival time of homozygous mutant mice in vivo. "
4.	Infections 01/01/2019 - "FOXO1 inhibition by AS1842856 makes resting T cells permissive to HIV-1 infection. " 12/18/2015 - "Repression of DIO2 by FOXO1 was confirmed using its specific inhibitor AS1842856 or adenoviral infection of constitutively active FOXO1. " 01/01/2014 - "The Foxo1 inhibitor AS1842856 accelerated de novo viral gene expression and the sequella of infection, supporting the notion that HIV-1 suppression of Foxo1 activity may be a strategy to promote replication in resting CD4 T cells. "
5.	Neoplasms (Cancer) 01/01/2023 - "We treated a set of BBC and GBM cancer cell lines with increasing concentrations of AS1842856 and found reduced colony formation. " 01/01/2023 - "Given the critical role of cancer stem cells in promoting cancer progression, we examined the impact of FOXO1 inhibition with AS1842856 (a cell-permeable small molecule that directly binds to unphosphorylated FOXO1 protein to block transcriptional regulation) on BBC and GBM cell viability. " 12/01/2022 - "We also found that the small molecule AS1842856, a FoxO1 inhibitor, promotes TERC expression and reverses the PD-L1 upregulation caused by chemotherapy, providing a potential combination cancer therapy that avoids cancer immune escape during chemotherapy." 01/01/2023 - "Treatment of BBC and GBM cancer cells with AS1842856 led to increases in FAS (FAS cell surface death receptor) and BIM (BCL2L11) gene expression, as well as increased positivity for markers for apoptosis such as annexin V and propidium iodide. "

Related Drugs and Biologics

1.	Reactive Oxygen Species (Oxygen Radicals)
2.	Adenosine Triphosphate (ATP)
3.	Small Interfering RNA (siRNA)
4.	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)
5.	fas Receptor (CD95 Antigen)
6.	Annexin A5
7.	Propidium (Propidium Iodide)
8.	Allergens
9.	Forkhead Box Protein O1
10.	omipalisib

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)