gamithromycin

an antibiotic used in cattle

Also Known As:

ZACTRAN; 1-Oxa-7-azacyclopentadecan-15-one,13-((2,6-dideoy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy 3,5,8,10,12,14-hexamethyl-7-propyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-, ((2R*, 3S*,4R*,5S*,8R*,10R*,11R*,12S*,13S*,14R*))-

Networked: 26 relevant articles (4 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Huang, Rose: 3 articles (12/2022 - 12/2021)
2.	Hamel, Dietmar: 2 articles (12/2022 - 12/2021)
3.	Pardon, Bart: 2 articles (12/2020 - 03/2016)
4.	Ding, Huanzhong: 2 articles (01/2020 - 01/2019)
5.	Venner, M: 2 articles (08/2017 - 01/2015)
6.	Croubels, Siska: 2 articles (03/2016 - 12/2015)
7.	De Backer, Patrick: 2 articles (03/2016 - 12/2015)
8.	De Baere, Siegrid: 2 articles (03/2016 - 12/2015)
9.	Plessers, Elke: 2 articles (03/2016 - 12/2015)
10.	Watteyn, Anneleen: 2 articles (03/2016 - 12/2015)

Related Diseases

1.	Bovine Respiratory Disease Complex 06/01/2013 - "Field study of the comparative efficacy of gamithromycin and tulathromycin for the treatment of undifferentiated bovine respiratory disease complex in beef feedlot calves." 06/01/2013 - "To compare the efficacy of gamithromycin with that of tulathromycin for control of undifferentiated bovine respiratory disease complex (BRDC) in feedlot calves. " 06/01/2013 - "To compare the efficacy of gamithromycin with that of tulathromycin for the treatment of undifferentiated bovine respiratory disease complex (BRDC) in feedlot calves. " 06/01/2013 - "Field study of the comparative efficacy of gamithromycin and tulathromycin for the control of undifferentiated bovine respiratory disease complex in beef feedlot calves at high risk of developing respiratory tract disease."
2.	Infections 02/01/2011 - "The antibacterial efficacy of gamithromycin administered once 1, 5, or 10 days prior to a challenge infection with Mannheimia haemolytica serotype A1 was evaluated. " 01/01/2019 - "In this study, multiple dosage regimens were administered to the neutropenic mouse lung infection model in order to investigate the pharmacokinetic/pharmacodynamic (PK/PD) parameters of gamithromycin treatment of P. " 12/09/2020 - "bovis infections, with a small remark for gamithromycin, is likely sufficient." 01/01/2019 - "Pharmacokinetics and Pharmacodynamics of Gamithromycin Treatment of Pasteurella multocida in a Murine Lung Infection Model." 01/01/2020 - "Increased Antimicrobial Activity of Colistin in Combination With Gamithromycin Against Pasteurella multocida in a Neutropenic Murine Lung Infection Model."
3.	Respiratory Tract Diseases (Respiratory Tract Disease) 01/01/2022 - "Gamithromycin is a long-acting azalide antibiotic that has been developed recently for the treatment of swine respiratory diseases. " 03/05/2020 - "Gamithromycin is a macrolide approved for the treatment of bovine and swine respiratory diseases. " 06/01/2013 - "Field study of the comparative efficacy of gamithromycin and tulathromycin for the control of undifferentiated bovine respiratory disease complex in beef feedlot calves at high risk of developing respiratory tract disease."
4.	Bronchopneumonia 01/01/2015 - "Gamithromycin is effective for the treatment of bronchopneumonia in foals. " 01/01/2015 - "Efficacy of gamithromycin for the treatment of foals with mild to moderate bronchopneumonia." 01/01/2015 - "Gamithromycin is active in vitro against the bacterial agents most commonly associated with bronchopneumonia in older foals. " 01/01/2015 - "Gamithromycin was noninferior to azithromycin with rifampin for the treatment of bronchopneumonia in the study population but had a higher frequency of adverse reactions."
5.	Body Weight (Weight, Body) 02/01/2014 - "The aim of this study was to investigate the pharmacokinetic properties of gamithromycin in pigs after an intravenous (i.v.) or subcutaneous (s.c.) bolus injection of 6 mg/kg body weight. " 02/01/2012 - "A single dose of gamithromycin (6 mg/kg of body weight) was administered intramuscularly. " 02/01/2011 - "Forty calves were randomly allocated on day -11, restricted by body weight, to one of three treatment groups given gamithromycin at 6 mg/kg of body weight 10, 5, or 1 days before challenge or to an untreated control group. " 12/01/2022 - "Metabolite profiles of gamithromycin in edible tissues of sheep treated with 6 mg/kg body weight subcutaneous injections were obtained with HRMS. " 12/01/2021 - "The basic pharmacokinetic parameters established in healthy young Merino sheep administered gamithromycin at 6 mg/kg body weight based on the analysis of plasma samples which were collected in intervals up to 12 days after subcutaneous injection were: area under the curve until last quantifiable concentration, 8.88 ± 2.33 μg*h/mL; maximum plasma concentration, 448 ± 180 ng/mL; terminal half-life, 42.5 ± 5.25 h. "

Related Drugs and Biologics

1.	tulathromycin
2.	Macrolides
3.	Lipopolysaccharides
4.	Anti-Bacterial Agents (Antibiotics)
5.	Solutions
6.	florfenicol
7.	Azithromycin (Zithromax)
8.	Rifampin (Rifampicin)
9.	Dexamethasone (Maxidex)
10.	marbofloxacin

Related Therapies and Procedures

1.	Subcutaneous Injections
2.	Retreatment
3.	Injections

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