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2- (1- hydroxyundecyl)- 1- (4- nitrophenylamino)- 6- phenyl- 6,7a- dihydro- 1H- pyrrolo(3,4- b)pyridine- 5,7(2H,4aH)- dione

a potent inhibitor of the phosphatase activity of human polynucleotide kinase/phosphatase; structure in first source

Also Known As:

A12B4C3

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - 2-(1-hydroxyundecyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo(3,4-b)pyridine-5,7(2H,4aH)-dione: 4

Experts

1.	Weinfeld, Michael: 3 articles (05/2014 - 10/2009)
2.	Freschauf, Gary K: 2 articles (01/2010 - 10/2009)
3.	Hall, Dennis G: 2 articles (01/2010 - 10/2009)
4.	Mereniuk, Todd R: 2 articles (01/2010 - 10/2009)
5.	Bergstrom, Dane: 1 article (05/2014)
6.	Cai, Zhongli: 1 article (05/2014)
7.	Leyton, Jeffrey V: 1 article (05/2014)
8.	Reilly, Raymond M: 1 article (05/2014)
9.	Zereshkian, Arman: 1 article (05/2014)
10.	Dianov, Grigory L: 1 article (01/2010)

Related Diseases

1.	Lung Neoplasms (Lung Cancer) 01/22/2010 - "Cellular studies revealed that A12B4C3 sensitizes A549 human lung cancer cells to the topoisomerase I poison, camptothecin, but not the topoisomerase II poison, etoposide, in a manner similar to small interfering RNA against PNKP. "
2.	Ovarian Neoplasms (Ovarian Cancer) 09/28/2023 - "DNA Double-Strand Break Repair Inhibitors: YU238259, A12B4C3 and DDRI-18 Overcome the Cisplatin Resistance in Human Ovarian Cancer Cells, but Not under Hypoxia Conditions."
3.	Myeloid Leukemia (Leukemia, Myelocytic) 05/01/2014 - "The human polynucleotide kinase/phosphatase (hPNKP) inhibitor A12B4C3 radiosensitizes human myeloid leukemia cells to Auger electron-emitting anti-CD123 ¹¹¹In-NLS-7G3 radioimmunoconjugates."
4.	Carcinoma (Carcinomatosis) 10/01/2009 - "At a nontoxic dose (1 micromol/L), A12B4C3 enhanced the radiosensitivity of human A549 lung carcinoma and MDA-MB-231 breast adenocarcinoma cells by a factor of two, which was almost identical to the increased sensitivity resulting from shRNA-mediated depletion of hPNKP. "
5.	Hypoxia (Hypoxemia) 09/28/2023 - "DNA Double-Strand Break Repair Inhibitors: YU238259, A12B4C3 and DDRI-18 Overcome the Cisplatin Resistance in Human Ovarian Cancer Cells, but Not under Hypoxia Conditions."

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	Poisons
3.	Etoposide (VP 16)
4.	Type I DNA Topoisomerases (Topoisomerase I)
5.	Type II DNA Topoisomerases (Topoisomerase II)
6.	Camptothecin
7.	Immunoconjugates (Immunoconjugate)
8.	Polynucleotide 5'-Hydroxyl-Kinase (Kinase, Polynucleotide)
9.	Phosphoric Monoester Hydrolases (Phosphatases)
10.	DNA (Deoxyribonucleic Acid)