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N- ((3- (carboxymethyl)- 2- oxoimidazolidin- 1- yl)acetyl)- l- valyl- N- ((3S)- 1,1,1- trifluoro- 4- methyl- 2- oxopentan- 3- yl)- l- prolinamide

structure in first source

Also Known As:

AE-3763

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - N-((3-(carboxymethyl)-2-oxoimidazolidin-1-yl)acetyl)-l-valyl-N-((3S)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl)-l-prolinamide: 2

Experts

1.	Inoue, Yasunao: 1 article (11/2009)
2.	Kubo, Taeko: 1 article (11/2009)
3.	Kuromiya, Akemi: 1 article (11/2009)
4.	Okazaki, Hiroshi: 1 article (11/2009)
5.	Omodani, Tomoki: 1 article (11/2009)
6.	Sato, Fuminori: 1 article (11/2009)
7.	Shiratake, Ryotaro: 1 article (11/2009)
8.	Ohbayashi, Hiroyuki: 1 article (07/2002)

Related Diseases

1.	Lung Injury 11/01/2009 - "Among these compounds, AE-3763 showed remarkable efficacy in hamster models of elastase-induced lung hemorrhage and lipopolysaccharide (LPS)-induced lung injury as well as in a mouse model of LPS/galactosamine-induced acute multiple organ dysfunctions. "
2.	Hemorrhage 11/01/2009 - "Among these compounds, AE-3763 showed remarkable efficacy in hamster models of elastase-induced lung hemorrhage and lipopolysaccharide (LPS)-induced lung injury as well as in a mouse model of LPS/galactosamine-induced acute multiple organ dysfunctions. "
3.	Chronic Obstructive Pulmonary Disease (COPD) 11/01/2009 - "Thus, it is believed that AE-3763 would be useful for treatment of HNE-associated respiratory disorders, such as acute respiratory distress syndrome (ARDS), acute lung injury (ALI), and acute exacerbation of chronic obstructive pulmonary disease (COPD)." 07/01/2002 - "In the application of chronic obstructive pulmonary disease therapy, the human neutrophil elastase inhibitors mainly focused upon include ONO-5046, MR-889, L-694,458, CE-1037, GW-311616 and TEI-8362 as the acyl-enzyme inhibitors; and ONO-6818, AE-3763, FK-706, ICI-200,880, ZD-0892 and ZD-8321 as the transition-state inhibitors. "
4.	Acute Lung Injury 11/01/2009 - "Thus, it is believed that AE-3763 would be useful for treatment of HNE-associated respiratory disorders, such as acute respiratory distress syndrome (ARDS), acute lung injury (ALI), and acute exacerbation of chronic obstructive pulmonary disease (COPD)."
5.	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 11/01/2009 - "Thus, it is believed that AE-3763 would be useful for treatment of HNE-associated respiratory disorders, such as acute respiratory distress syndrome (ARDS), acute lung injury (ALI), and acute exacerbation of chronic obstructive pulmonary disease (COPD)."

Related Drugs and Biologics

1.	Pancreatic Elastase (Elastase)
2.	Lipopolysaccharides
3.	Galactosamine
4.	Secretory Proteinase Inhibitory Proteins
5.	Enzyme Inhibitors (Inhibitors, Enzyme)
6.	ONO 6818
7.	TEI 8362
8.	ZD 0892
9.	ZD 8321
10.	DMP 777

Related Therapies and Procedures

1.	Therapeutics