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CJ 15,208

isolated from Ctenomyces serratus; structure in first source

Also Known As:

CJ 15208; CJ-15,208; CJ-15208; CJ15,208; cyclo(Phe-d-Pro-Phe-Trp)

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - CJ 15,208: 3
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - CJ 15,208: 3

Experts

1.	Aldrich, Jane V: 3 articles (01/2022 - 08/2017)
2.	McLaughlin, Jay P: 2 articles (01/2022 - 01/2020)
3.	Brice-Tutt, Ariana C: 1 article (01/2020)
4.	Coleman, Jeremy S: 1 article (01/2020)
5.	Eans, Shainnel O: 1 article (01/2020)
6.	Ferracane, Michael J: 1 article (01/2020)
7.	Murray, Thomas F: 1 article (01/2020)
8.	Simpson, Grant G: 1 article (01/2020)
9.	Stacy, Heather M: 1 article (01/2020)
10.	Wilson, Lisa L: 1 article (01/2020)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 08/03/2017 - "Thus [D-Trp]CJ-15,208 represents a new lead compound for the potential development of an effective treatment of prostate cancer." 08/03/2017 - "[D-Trp]CJ-15,208 reduced c-Myc protein levels in prostate cancer cells and decreased cell proliferation with IC50 values ranging from 2.0 to 16 µM in multiple PC cell lines. "
2.	Neoplasms (Cancer) 08/03/2017 - "In this study, we report the anti-cancer activity of the macrocyclic peptides [D-Trp]CJ-15,208 (cyclo[Phe-D-Pro-Phe-D-Trp]) and the natural product CJ-15,208 (cyclo[Phe-D-Pro-Phe-Trp]). "
3.	Substance-Related Disorders (Drug Abuse) 01/01/2020 - "Macrocyclic tetrapeptides like CJ-15,208 and [d-Trp]CJ-15,208 demonstrate opioid activity shown to attenuate the rewarding effects of cocaine in conditioned place preference assays in mice, making them promising lead compounds for treating substance abuse. " 01/01/2022 - "Following a brief discussion of the potential therapeutic applications of KOR agonists and antagonists, this review focuses on two series of novel opioid peptides, all-D-amino acid tetrapeptides as peripherally selective KOR agonists for the treatment of pain and pruritus without centrally mediated side effects, and macrocyclic tetrapeptides based on CJ-15,208 that can exhibit different opioid profiles with potential applications such as analgesics and treatments for substance abuse."
4.	Pruritus (Itching) 01/01/2022 - "Following a brief discussion of the potential therapeutic applications of KOR agonists and antagonists, this review focuses on two series of novel opioid peptides, all-D-amino acid tetrapeptides as peripherally selective KOR agonists for the treatment of pain and pruritus without centrally mediated side effects, and macrocyclic tetrapeptides based on CJ-15,208 that can exhibit different opioid profiles with potential applications such as analgesics and treatments for substance abuse."
5.	Pain (Aches) 01/01/2022 - "Following a brief discussion of the potential therapeutic applications of KOR agonists and antagonists, this review focuses on two series of novel opioid peptides, all-D-amino acid tetrapeptides as peripherally selective KOR agonists for the treatment of pain and pruritus without centrally mediated side effects, and macrocyclic tetrapeptides based on CJ-15,208 that can exhibit different opioid profiles with potential applications such as analgesics and treatments for substance abuse."

Related Drugs and Biologics

1.	CJ 15,208
2.	Peptides (Polypeptides)
3.	Opioid Analgesics (Opioids)
4.	Opioid Peptides (Opioid Peptide)
5.	Proteins (Proteins, Gene)
6.	Cocaine (Cocaine HCl)
7.	Analgesics (Analgesic Drugs)
8.	Amino Acids