HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

2- cyano- 1- ((1S)- 1- phenylethyl)- 3- quinolin- 5- ylguanidine

a potent and selective antagonist radioligand for P2X7 receptors; structure in first source

Also Known As:

(3H)2-cyano-1-((1S)-1-phenylethyl)-3-quinolin-5-ylguanidine; A-804598; A804598

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Guanidines: 29
    - 2-cyano-1-((1S)-1-phenylethyl)-3-quinolin-5-ylguanidine: 2
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - 2-cyano-1-((1S)-1-phenylethyl)-3-quinolin-5-ylguanidine: 2

Experts

1.	Asatryan, Liana: 1 article (01/2019)
2.	Baghram, Ared: 1 article (01/2019)
3.	Davies, Daryl L: 1 article (01/2019)
4.	Freire, Daniel: 1 article (01/2019)
5.	Reyes, Rachel E: 1 article (01/2019)
6.	Han, Jung Hyun: 1 article (01/2017)
7.	Jung, Young-Hwan: 1 article (01/2017)
8.	Kim, Yeo Ok: 1 article (01/2017)
9.	Kim, Yong-Chul: 1 article (01/2017)
10.	Yoon, Myung Ha: 1 article (01/2017)

Related Diseases

1.	Hyperalgesia 01/01/2017 - "These results demonstrated that intrathecal combination of BRL52537, pregabalin, AF 353, and A804598 synergistically or additively attenuated allodynia evoked by SNL, which suggests the possibility to improve the efficacy of single-drug administration."
2.	Neuroinflammatory Diseases 01/01/2019 - "In the present study, we tested the potential of P2X7R antagonist A804598 to reduce/abolish alcohol-induced neuroinflammation using chronic intragastric ethanol infusion and high-fat diet (Hybrid) in C57BL/6J mice. "
3.	Inflammation (Inflammations) 01/01/2019 - "P2X7 Receptor Antagonist A804598 Inhibits Inflammation in Brain and Liver in C57BL/6J Mice Exposed to Chronic Ethanol and High Fat Diet."

Related Drugs and Biologics

1.	Pregabalin (Lyrica)
2.	5- (5- iodo- 2- isopropyl- 4- methoxyphenoxy)pyrimidine- 2,4- diamine
3.	1- (3,4- dichlorophenyl)acetyl- 2- (1- pyrrolidinyl)methylpiperidine
4.	Ethanol (Ethyl Alcohol)
5.	Purinergic P2X7 Receptors