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peptibody A

consists of an IgG-Fc with 2 C-terminal peptide arms linked with spacers

Also Known As:

PbA peptibody

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Recombinant Proteins: 2754
    - Recombinant Fusion Proteins: 333
      - peptibody A: 2

Experts

1.	Chen, Zihong: 1 article (01/2017)
2.	Dong, Jiangling: 1 article (01/2017)
3.	Dong, Yanjun: 1 article (01/2017)
4.	Mitch, William E: 1 article (01/2017)
5.	Zhang, Liping: 1 article (01/2017)
6.	Bass, Michael B: 1 article (12/2012)
7.	Deptala, Andrzej: 1 article (12/2012)
8.	Dirix, Luc Y: 1 article (12/2012)
9.	Escudier, Bernard: 1 article (12/2012)
10.	Fishman, Mayer: 1 article (12/2012)

Related Diseases

1.	Clear-cell metastatic renal cell carcinoma 12/15/2012 - "This study evaluated the tolerability and antitumor activity of AMG 386, a peptibody (a peptide Fc fusion) that neutralizes the interaction of angiopoietin-1 and angiopoietin-2 with Tie2 (tyrosine kinase with immunoglobulin-like and EGF-like domains 2), plus sorafenib in patients with clear cell metastatic renal cell carcinoma (mRCC) in a randomized controlled study. "
2.	Fibrosis (Cirrhosis) 01/01/2017 - "When myostatin was inhibited with a neutralizing peptibody (a chimeric peptide-Fc fusion protein), the FAP proliferation and muscle fibrosis induced by CKD were both suppressed. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	TIE-2 Receptor (Receptor, TIE 2)
3.	Angiopoietin-2
4.	Angiopoietin-1
5.	Immunoglobulins (Immunoglobulin)
6.	Epidermal Growth Factor (EGF)
7.	Sorafenib (BAY 43-9006)
8.	trebananib
9.	Myostatin
10.	Proteins (Proteins, Gene)