Keshan disease

Congestive cardiomyopathy that may be associated with a dietary deficiency of SELENIUM or infection by COXSACKIE B VIRUSES. It is most prevalent in rural Chinese populations, especially in young boys and women of childbearing age.

Networked: 175 relevant articles (7 outcomes, 35 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Heart Failure
2.	Cardiomyopathies (Cardiomyopathy)
3.	Infections
4.	Kashin-Beck Disease
5.	Heart Diseases (Heart Disease)

Experts

1.	Wang, Tong: 10 articles (01/2022 - 12/2010)
2.	Hou, Jie: 7 articles (01/2022 - 12/2011)
3.	Wang, Yanan: 7 articles (01/2022 - 01/2019)
4.	Zhou, Huihui: 7 articles (12/2021 - 11/2018)
5.	Wei, Jin: 7 articles (11/2020 - 02/2007)
6.	Liang, Hong: 6 articles (12/2021 - 01/2019)
7.	Zhang, Xiao: 6 articles (12/2021 - 01/2019)
8.	Guo, Xiong: 6 articles (11/2019 - 05/2017)
9.	Tan, Wuhong: 6 articles (11/2019 - 05/2013)
10.	Li, Qi: 5 articles (01/2022 - 12/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Keshan disease:

1.	SeleniumIBA 03/30/1994 - "Previous studies have shown the pathogenic effects of grains cultivated in the endemic areas of Keshan disease and selenium is effective in the prevention of this disease. " 07/01/2010 - "The selenium nutritional status of residents has improved, and the prevalence of Keshan disease is expected to be decreased in these areas." 12/01/2021 - "A Spatial Ecological Study on Hair Selenium Level of Residents in Keshan Disease Endemic and Non-endemic Areas in Heilongjiang Province, China." 09/01/2021 - "A Spatial Ecological Study on Serum Selenium and Keshan Disease in Heilongjiang Province, China." 06/01/2019 - "Few spatial ecological studies on hair selenium (Se) and Keshan disease (KD) have been reported. "
2.	Sodium SeleniteIBA 05/01/1991 - "Twelve health adults (6 M, 6 F) from the endemic area of Keshan disease and Kaschin-Beck's disease and 12 adults from nonaffected area were administered a single oral dose of 4 mg sodium selenite. " 03/01/1990 - "Sodium selenite has been used for prevention and treatment of Keshan disease and Kaschin-Beck's disease. " 07/01/1979 - "Observations on effect of sodium selenite in prevention of Keshan disease." 11/01/1982 - "The use of soy-beans to improve the diet and oral administration of sodium selenite will prevent Keshan disease. " 01/01/1990 - "Correction of selenium deficiency with sodium selenite reduced to the minimum the mortality rate from endemic cardiopathy in China (Keshan disease) and had a favourable effect on other forms of cardiovascular pathology. "
3.	Biomarkers (Surrogate Marker)IBA 12/01/2017 - "The above results might be beneficial for further biomarkers discovery and Keshan disease pathological mechanism study." 11/11/2020 - "This study aims to identify biomarkers for the early diagnosis and further explore new therapeutic targets for Keshan disease. " 11/11/2020 - "Finally, deep mining of big data and rapid machine learning will be employed to analyze the baseline data, experimental data, and clinical data to seek out the new biomarkers to predict the pathogenesis of Keshan disease. " 08/01/2014 - "Serum biomarkers of Keshan disease assessed using a protein profiling approach based on ClinProt technique."
4.	Vitamin EFDA LinkGeneric 06/01/1993 - "Vitamin E requirement of rats fed on a diet containing grains from the endemic region of Keshan disease." 07/01/1990 - "[Protective effects of vitamin E and selenium on myocardial mitochondria in rats--a study on the pathogenic factors and pathogenesis of Keshan disease]." 07/01/1990 - "The protective effects of vitamin E (VE) and selenium (Se) on myocardial mitochondria were investigated in rats fed grains (with 0.006 ppm Se) from an endemic area of Keshan disease. " 07/01/2011 - "Oxidative stress induced by the combined deficiencies of selenium (Se) and vitamin E (VE) is considered the basic factor of Keshan disease (KD). " 04/01/1998 - "Alterations in rat pancreatic islet beta cells induced by Keshan disease pathogenic factors: protective action of selenium and vitamin E."
5.	LipidsIBA 01/01/2021 - "Small clinical trials assessing selenium supplementation in patients with HF showed improvement of clinical symptoms (NYHA class), left ventricular ejection fraction, and lipid profile, while governmental interventional programs in endemic areas have significantly decreased the incidence of Keshan disease. " 06/01/1983 - "[Plasma and erythrocyte levels of selenium and lipids in children with Keshan disease and their pathogenic significance]."
6.	TabletsIBA 01/01/2012 - "Several large population based intervention trials using oral administration of sodium selenite tablets showed significant reduction of Keshan disease incidence. "
7.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 04/01/2019 - "Our ten-year follow-up analysis indicated that selenium supplementation, specifically combined with the use of angiotensin-converting enzyme inhibitor and beta blocker therapy, improved the survival of patients with chronic Keshan disease with congestive heart failure. "
8.	Selenoprotein PIBA 01/01/2022 - "A County-Level Spatial Study of Serum Selenoprotein P and Keshan Disease." 09/03/2021 - "Few spatial studies on Keshan disease (KD) prevalence and serum selenoprotein P (SELENOP) levels have been reported in the Heilongjiang Province, China. " 09/03/2021 - "A spatial study on Keshan disease prevalence and selenoprotein P in the Heilongjiang Province, China." 05/01/2021 - "Few spatial studies on serum selenoprotein P (SELENOP) and Keshan disease (KD) have been reported at the county-level in Heilongjiang province, China. " 05/01/2021 - "A spatial study on serum selenoprotein P and Keshan disease in Heilongjiang Province, China."
9.	Proteins (Proteins, Gene)FDA Link 12/01/2017 - "In the current study, isobaric tags for relative and absolute quantitation (iTRAQ) labeling coupled with two-dimensional liquid chromatography-tandem mass spectrometry (2D-LC-MS/MS) was firstly used to screen for the differentially expressed proteins (DEPs) in serum between Keshan disease and healthy residents in endemic area. " 05/01/2013 - "[Screening of differentially expressed proteins in serum from subjects with Keshan disease by two-dimensional electrophoresis and mass and mass spectrometry]." 05/01/2013 - "Differentially expressed protein spots were screened by two-dimensional gel electrophoresis (2-DE) between Keshan disease and health control subjects, and constitutive protein were identified by matrix assisted laser adsorption/ionization-time of flight mass spectrometry (MALDI-TOF-MS). " 05/01/2018 - "Network Analysis of Se-and Zn-related Proteins in the Serum Proteomics Expression Profile of the Endemic Dilated Cardiomyopathy Keshan Disease." 12/01/2019 - "Studies have shown that selenium deficiency and low protein(Pr) intake are the primary risk factors for Keshan disease.The"
10.	Glutathione PeroxidaseIBA 05/11/2020 - "BACKGROUND Glutathione peroxidase 8 (GPX8) has previously been shown to play a role in Keshan disease. " 12/01/1991 - "Chinese scientists also carried out a study in an area where Keshan disease was prevalent to determine the amount of dietary selenium needed to maximize the activity of the selenium-containing enzyme, glutathione peroxidase, in plasma. " 01/01/2001 - "In order to study the effect of dietary methionine on tissue selenium and glutathione peroxidase activity(GPX) in rats fed on grains from Keshan Disease endemic area, a nonpurified selenium (Se) deficient diet (containing Se 0.007 mg/kg diet) taken from Keshan Disease endemic area was supplemented with selenomethionine (SeMet) to provide selenium content in diet for 0.007, 0.06 and 0.50 mg/kg and added or not added with DL-methionine (Met) 4 g/kg to make 6 kinds of diet. "

Therapies and Procedures

1.	Oral Administration 11/01/1982 - "The use of soy-beans to improve the diet and oral administration of sodium selenite will prevent Keshan disease. " 01/01/2012 - "Several large population based intervention trials using oral administration of sodium selenite tablets showed significant reduction of Keshan disease incidence. "
2.	Therapeutics 04/01/2019 - "Our ten-year follow-up analysis indicated that selenium supplementation, specifically combined with the use of angiotensin-converting enzyme inhibitor and beta blocker therapy, improved the survival of patients with chronic Keshan disease with congestive heart failure. "
3.	Parenteral Nutrition 05/01/2002 - "MMN lesions are observed in various pathologic conditions including cystic fibrosis of the pancreas, pancreatic lipomatous hypoplasia/atrophy, malnutrition due to extensive intestinal resection with subsequent total parenteral feeding, and in Keshan disease. " 01/01/1990 - "Biogeochemical anomalies, parenteral nutrition, malabsorption syndromes as conditions for the development of hyposelenosis are characterized as well as their manifestations (white-muscular disease, myopathies, cardiomyopathies, Keshan disease, Kashin-Beck disease). "
4.	Cardiac Catheters 09/01/1997 - "Selenium supplements were not able to restore the ultrastructural changes in the myocardium of latent Keshan disease patients taken by using cardiac catheter endomyocardial biopsy. "
5.	Total Parenteral Nutrition 11/01/1989 - "Selenium deficiency has been implicated in the pathogenesis of a dilated congestive cardiomyopathy in areas of China (Keshan disease) and in several patients on long-term total parenteral nutrition. "