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thieleanin
isolated from Decachaeta thieleana; structure in first source
Networked:
1
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Terpenes: 1461
Sesquiterpenes: 1370
thieleanin: 1
Lactones: 1549
thieleanin: 1
Experts
1.
Bonilla, José A
: 1 article (09/2008)
2.
Dupuy Loo, Omar A
: 1 article (09/2008)
3.
Murillo, Renato
: 1 article (09/2008)
4.
Taylor, Peter G
: 1 article (09/2008)
Related Diseases
1.
Neoplasms (Cancer)
09/01/2008 - "
In contrast, treatment with thieleanin (8 mg/kg every other day up to the day of kill) neither retarded the appearance of the tumor nor its growth.
"
09/01/2008 - "
The present study was carried out in order to examine the anticancer properties of two sesquiterpene lactones, millerenolide and thieleanin, isolated from Viguiera sylvatica and Decachaeta thieleana, against cell lines in vitro, and on the growth B16/BL6 melanoma tumors in C57BL/6 mice.
"
2.
Melanoma (Melanoma, Malignant)
09/01/2008 - "
The parent 3T3 cells and the B16/BL6 mouse melanoma cells were less sensitive to these compounds, with thieleanin showing an IC(50) with B16/BL6 greater than the highest dose tested (203 microM).
"
09/01/2008 - "
The present study was carried out in order to examine the anticancer properties of two sesquiterpene lactones, millerenolide and thieleanin, isolated from Viguiera sylvatica and Decachaeta thieleana, against cell lines in vitro, and on the growth B16/BL6 melanoma tumors in C57BL/6 mice.
"
3.
Lung Neoplasms (Lung Cancer)
09/01/2008 - "
Millerenolide and thieleanin showed a similar pattern of cytotoxicity with the greatest effect on viability being evident with A549 human lung cancer cells (IC(50) - 40 and 32 microM respectively), and with the 3T3/HER2 cell line which are 3T3 mouse fibroblasts transfected with the HER2 oncogene (IC(50) - 16 and 28 microM respectively).
"
Related Drugs and Biologics
1.
Sesquiterpenes
2.
Lactones
3.
millerenolide