1- (2- (2- (3,4- dichlorophenyl)- 4- (3,4,5- trimethoxybenzoyl)morpholin- 2- yl)ethyl)spiro(benzo(c)thiophene- 1(3H),4'- piperidine)- 2- oxide

TNRA - triple neurokinin receptor antagonist; structure in first source

Also Known As:

CS 003; CS-003; CS003; TNRA cpd

Networked: 3 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Cyclic S-Oxides
    - 1-(2-(2-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl)ethyl)spiro(benzo(c)thiophene-1(3H),4'-piperidine)-2-oxide: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Oxazines: 9
    - Morpholines: 6
      - 1-(2-(2-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl)ethyl)spiro(benzo(c)thiophene-1(3H),4'-piperidine)-2-oxide: 3
- Heterocyclic Oxides
  - Cyclic S-Oxides
    - 1-(2-(2-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl)ethyl)spiro(benzo(c)thiophene-1(3H),4'-piperidine)-2-oxide: 3

Experts

1.	Morimoto, Kiyoshi: 2 articles (10/2008 - 05/2008)
2.	Nosaka, Emi: 2 articles (10/2008 - 05/2008)
3.	Takahashi, Sakiko: 2 articles (10/2008 - 05/2008)
4.	Tsuchida, Hiroshi: 2 articles (10/2008 - 05/2008)
5.	Yamashita, Makoto: 2 articles (10/2008 - 05/2008)
6.	Kuraya, Takako: 1 article (10/2008)
7.	Mukaiyama, Osamu: 1 article (05/2008)
8.	Heyrman, R: 1 article (01/2006)
9.	Joos, G: 1 article (01/2006)
10.	Lenz, W: 1 article (01/2006)

Related Diseases

1.	Respiratory Tract Diseases (Respiratory Tract Disease) 05/31/2008 - "CS-003 is a potent antagonist of triple neurokinin receptors and may achieve the best therapeutic efficacy on respiratory diseases associated with neurokinins compared to selective neurokinin receptor antagonists." 10/31/2008 - "These data show that CS-003, a potent orally active triple neurokinin receptor antagonist, may be useful for the treatment of respiratory diseases associated with neurokinins, such as allergic asthma, allergic rhinitis, chronic obstructive pulmonary disease and cough."
2.	Cough 05/31/2008 - "CS-003 significantly inhibited citric acid-induced coughs and the effect was greater than those of other selective neurokinin receptor antagonists. " 10/31/2008 - "These data show that CS-003, a potent orally active triple neurokinin receptor antagonist, may be useful for the treatment of respiratory diseases associated with neurokinins, such as allergic asthma, allergic rhinitis, chronic obstructive pulmonary disease and cough." 10/31/2008 - "CS-003 (10 mg/kg, p.o.) inhibited the number of coughs induced by capsaicin aerosol (P<0.01) and the antitussive effect was comparable to that of codeine. "
3.	Asthma (Bronchial Asthma) 01/01/2006 - "The triple neurokinin-receptor antagonist CS-003 inhibits neurokinin A-induced bronchoconstriction in patients with asthma." 10/31/2008 - "These data show that CS-003, a potent orally active triple neurokinin receptor antagonist, may be useful for the treatment of respiratory diseases associated with neurokinins, such as allergic asthma, allergic rhinitis, chronic obstructive pulmonary disease and cough." 10/31/2008 - "CS-003 (10 mg/kg, p.o.) also inhibited airway hyperresponsiveness to methacholine chloride in ovalbumin-induced asthma models (P<0.01), a milder one and a severer one. "
4.	Allergic Rhinitis 10/31/2008 - "These data show that CS-003, a potent orally active triple neurokinin receptor antagonist, may be useful for the treatment of respiratory diseases associated with neurokinins, such as allergic asthma, allergic rhinitis, chronic obstructive pulmonary disease and cough."
5.	Chronic Obstructive Pulmonary Disease (COPD) 10/31/2008 - "These data show that CS-003, a potent orally active triple neurokinin receptor antagonist, may be useful for the treatment of respiratory diseases associated with neurokinins, such as allergic asthma, allergic rhinitis, chronic obstructive pulmonary disease and cough."

Related Drugs and Biologics

1.	Citric Acid (Citrate)
2.	Methacholine Chloride (Methacholine)
3.	Neurokinin A
4.	Ovalbumin
5.	Dexamethasone (Maxidex)
6.	Codeine (Codeine Phosphate)
7.	Capsaicin (Zostrix)
8.	Antitussive Agents (Antitussives)
9.	Aerosols

Related Therapies and Procedures

1.	Oral Administration