HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

N,N'-bis(5-aminosalicyl)cystine

a 5-ASA prodrug for delivery of 5-ASA to the colon; structure in first source

Also Known As:

5-ASA-Cys; N,N'-bis(5-aminosalicyl)-L-cystine

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
Inorganic Chemicals: 9
- Electrolytes: 16106
  - Ions: 7857
    - Anions: 3501
      - Sulfides: 1062
        Disulfides: 2363
        Cystine: 2248
        N,N'-bis(5-aminosalicyl)cystine: 1
- Sulfur Compounds: 278
  - Hydrogen Sulfide: 2764
    - Sulfides: 1062
      - Disulfides: 2363
        Cystine: 2248
        N,N'-bis(5-aminosalicyl)cystine: 1
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675

Experts

1.	Choi, Daekyu: 1 article (01/2009)
2.	Han, Jungoh: 1 article (01/2009)
3.	Huh, Jeongsoon: 1 article (01/2009)
4.	Jeon, Hyunchu: 1 article (01/2009)
5.	Jung, Yunjin: 1 article (01/2009)
6.	Kim, Heejung: 1 article (01/2009)
7.	Kim, Youngmi: 1 article (01/2009)

Related Diseases

1.

01/01/2009 - "Oral administration of 5-ASA-Cys ameliorated experimental colitis of rats induced by TNBS, which was more effective than that of sulfasalazine. "
01/01/2009 - "N,N'-Bis(5-aminosalicyl)-L-cystine is a potential colon-specific 5-aminosalicylic acid prodrug with dual therapeutic effects in experimental colitis."
01/01/2009 - "Taken together, these results suggest that 5-ASA-Cys is a potential colon specific 5-ASA prodrug with dual therapeutic effects on experimental colitis and cysteine modulation of the glutathione level may be relevant to the dual effects of the prodrug."
01/01/2009 - "To evaluate N,N'-bis(5-aminosalicyl)-L-cystine (5-ASA-Cys) as a potential colon-specific 5-aminosalicylic acid prodrug with dual therapeutic effects in experimental colitis, the pharmacokinetics and therapeutic activity were investigated after oral administration of 5-ASA-Cys and amelioration of experimental colitis was compared after rectal administration of 5-aminosalicylic acid (5-ASA) and/or cysteine. "

Related Drugs and Biologics

1.	N,N'-bis(5-aminosalicyl)cystine
2.	Therapeutic Uses
3.	Mesalamine (Mesalazine)
4.	Sulfasalazine (Azulfidine)
5.	Prodrugs
6.	Glutathione (Reduced Glutathione)
7.	Cysteine (L-Cysteine)

Related Therapies and Procedures

1.	Rectal Administration
2.	Oral Administration