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clausine-B

from the ethyl acetate extract of the stem bark of the Malaysian Clausena excavata.; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Carbazoles: 32
        clausine-B: 1
  - 3-Ring Heterocyclic Compounds
    - Carbazoles: 32
      - clausine-B: 1

Experts

1.	Othman, Fauziah: 1 article (07/2009)
2.	Rahmat, Asmah: 1 article (07/2009)
3.	Wan Mohd Zain, Wan Nor I'zzah: 1 article (07/2009)
4.	Yap, Taufiq Yun Hin: 1 article (07/2009)

Related Diseases

1.	Ovarian Neoplasms (Ovarian Cancer) 07/01/2009 - "CLAUSINE B, A CARBAZOLE ALKALOID ISOLATED FROM THE STEM BARK OF CLAUSENA EXCAVATA, WAS INVESTIGATED FOR ITS ANTIPROLIFERATIVE ACTIVITIES AGAINST FIVE HUMAN CANCER CELL LINES: HepG2 (hepatic cancer), MCF-7 (hormone-dependent breast cancer), MDA-MB-231 (non-hormone-dependent breast cancer), HeLa (cervical cancer), and CAOV3 (ovarian cancer). "
2.	Neoplasms (Cancer) 07/01/2009 - "Clausine-B inhibited the MCF-7 cancer cell line at 52.90 μg/mL, and no IC(50) value was obtained against Chang liver. " 07/01/2009 - "Clausine-B was found to be active (IC(50)<30 μg/mL) against four of the cancer cell lines tested. " 07/01/2009 - "Antiproliferative Properties of Clausine-B against Cancer Cell Lines." 07/01/2009 - "CLAUSINE B, A CARBAZOLE ALKALOID ISOLATED FROM THE STEM BARK OF CLAUSENA EXCAVATA, WAS INVESTIGATED FOR ITS ANTIPROLIFERATIVE ACTIVITIES AGAINST FIVE HUMAN CANCER CELL LINES: HepG2 (hepatic cancer), MCF-7 (hormone-dependent breast cancer), MDA-MB-231 (non-hormone-dependent breast cancer), HeLa (cervical cancer), and CAOV3 (ovarian cancer). "
3.	Liver Neoplasms (Liver Cancer) 07/01/2009 - "CLAUSINE B, A CARBAZOLE ALKALOID ISOLATED FROM THE STEM BARK OF CLAUSENA EXCAVATA, WAS INVESTIGATED FOR ITS ANTIPROLIFERATIVE ACTIVITIES AGAINST FIVE HUMAN CANCER CELL LINES: HepG2 (hepatic cancer), MCF-7 (hormone-dependent breast cancer), MDA-MB-231 (non-hormone-dependent breast cancer), HeLa (cervical cancer), and CAOV3 (ovarian cancer). "
4.	Uterine Cervical Neoplasms (Cancer of the Cervix) 07/01/2009 - "CLAUSINE B, A CARBAZOLE ALKALOID ISOLATED FROM THE STEM BARK OF CLAUSENA EXCAVATA, WAS INVESTIGATED FOR ITS ANTIPROLIFERATIVE ACTIVITIES AGAINST FIVE HUMAN CANCER CELL LINES: HepG2 (hepatic cancer), MCF-7 (hormone-dependent breast cancer), MDA-MB-231 (non-hormone-dependent breast cancer), HeLa (cervical cancer), and CAOV3 (ovarian cancer). "
5.	Breast Neoplasms (Breast Cancer) 07/01/2009 - "CLAUSINE B, A CARBAZOLE ALKALOID ISOLATED FROM THE STEM BARK OF CLAUSENA EXCAVATA, WAS INVESTIGATED FOR ITS ANTIPROLIFERATIVE ACTIVITIES AGAINST FIVE HUMAN CANCER CELL LINES: HepG2 (hepatic cancer), MCF-7 (hormone-dependent breast cancer), MDA-MB-231 (non-hormone-dependent breast cancer), HeLa (cervical cancer), and CAOV3 (ovarian cancer). "

Related Drugs and Biologics

1.	Hormones (Hormone)
2.	Alkaloids
3.	carbazole