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AZD 7545

an anilide tertiary carbinol; a pyruvate dehydrogenase kinase 2 inhibitor

Also Known As:

AZD-7545; AZD7545; Nov3r compound

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - Anilides: 22
      - AZD 7545: 5
- Amides: 2428
  - Anilides: 22
    - AZD 7545: 5

Experts

1.	Bakker, Barbara M: 1 article (03/2022)
2.	Evers, Bernard: 1 article (03/2022)
3.	Jalving, Mathilde: 1 article (03/2022)
4.	Tiersma, Jiske F: 1 article (03/2022)
5.	de Jong, Steven: 1 article (03/2022)
6.	Bae, Sung-Jin: 1 article (11/2021)
7.	Cho, Minkyoung: 1 article (11/2021)
8.	Ha, Ki-Tae: 1 article (11/2021)
9.	Han, Jung Ho: 1 article (11/2021)
10.	Jin, Ling: 1 article (11/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "From the therapeutic perspective, reactivation of PDH in cancer cells that were weakly sensitive for reovirus, either through PDH kinase (PDK) inhibitors dichloroacetate and AZD7545 or short hairpin RNA-specific depletion of PDK1, enhanced the efficacy of reovirus-induced oncolysis in vitro and in vivo. " 11/01/2021 - "Leelamine, huzhangoside A and otobaphenol induced PDH activity-dependent apoptosis, whereas AZD7545, VER-246608 and DCA effectively enhanced PDHA1 activity but little toxic to cancer cells. "
2.	Melanoma (Melanoma, Malignant) 01/01/2017 - "Thus small molecule PDK inhibitors such as AZD7545, might be promising drugs for combination treatment in melanoma patients with activating RAS/RAF/MEK/ERK pathway mutations (50% BRAF, 25% NRASmut, 11.9% NF1mut)." 01/01/2017 - "We show that inhibition of PDKs by AZD7545 leads to growth suppression of BRAF-mutated and -inhibitor resistant melanoma cells. " 01/01/2017 - "Interestingly, the inhibition of PDK1 with AZD7545 specifically suppressed growth of BRAF-mutant and BRAF inhibitor resistant melanoma cells. " 03/29/2022 - "We aimed to reduce glucose uptake in melanoma cell lines through PDK inhibitors dichloroacetate (DCA) and AZD7545 and through PDK knockdown, to inhibit cell growth and potentially unveil metabolic co-vulnerabilities resulting from PDK inhibition. "
3.	Type 2 Diabetes Mellitus (MODY) 12/01/2003 - "AZD7545 is one of a series of PDH kinase inhibitors developed for the treatment of type 2 diabetes. "

Related Drugs and Biologics

1.	Pyruvate Dehydrogenase Acetyl-Transferring Kinase
2.	Small Interfering RNA (siRNA)
3.	Glucose (Dextrose)
4.	VER-246608
5.	dehydroabietylamine