PF-670462

inhibitor of casein kinase I epsilon; structure in first source

Also Known As:

4-(1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl)-2-pyrimidinamine dihydrochloride; 4-(3-cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl)pyrimidin-2-ylamine; PF670462

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - PF-670462: 6

Experts

1.	Chen, Chun-Han: 1 article (01/2020)
2.	Chen, Mei-Chuan: 1 article (01/2020)
3.	Hsieh, Tsung-Han: 1 article (01/2020)
4.	Lin, Yu-Chen: 1 article (01/2020)
5.	Liou, Jing-Ping: 1 article (01/2020)
6.	Hasegawa, Ayana: 1 article (12/2019)
7.	Kawano, Koji: 1 article (12/2019)
8.	Nagaoka, Kentaro: 1 article (12/2019)
9.	Ogawa, Misato: 1 article (12/2019)
10.	Ohmori, Keitaro: 1 article (12/2019)

Related Diseases

1.	Allergic Rhinitis 04/01/2016 - "PF670462 or dexamethasone also ameliorated allergic symptoms in a mouse model of allergic rhinitis and downregulated allergen-specific basophil reactivity in patients with allergic rhinitis. "
2.	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/01/2018 - "We have examined the abundance of CK1 delta and epsilon (CK1δ/ε) in lung tissue from IPF patients and non-diseased controls, and investigated whether inhibition of CK1δ/ε with PF670462 inhibits pulmonary fibrosis. " 01/01/2018 - "The CK1δ/ε inhibitor PF670462 administered systemically or locally by inhalation prevented both acute and chronic bleomycin-induced pulmonary fibrosis in mice. " 01/01/2018 - "Casein Kinase 1δ/ε Inhibitor, PF670462 Attenuates the Fibrogenic Effects of Transforming Growth Factor-β in Pulmonary Fibrosis."
3.	Neoplasms (Cancer) 06/02/2011 - "The recent development of the nanomolar CK1δ/ɛ-selective inhibitor, PF670462 (PF670) and the CK1ɛ-selective inhibitor PF4800567 (PF480) offers an opportunity to further test the role of CK1δ/ɛ in cancer. "
4.	Hypersensitivity (Allergy) 04/01/2016 - "We examined the effects of PF670462, a selective inhibitor of the key clock component casein kinase 1δ/ε, or glucocorticoid, both of which upregulated PER2 in mast cells, on IgE-mediated allergic reactions both in vitro and in vivo. " 04/01/2016 - "PF670462 or corticosterone (or dexamethasone) suppressed IgE-mediated allergic reactions in mouse bone marrow-derived mast cells or basophils and passive cutaneous anaphylactic reactions in mice in association with increased PER2 levels in mast cells or basophils. "
5.	Erythema 12/05/2019 - "Furthermore, PF670462 suppressed IgE-mediated immediate-type cutaneous erythema in dogs. "

Related Drugs and Biologics

1.	Casein Kinases (Casein Kinase)
2.	Immunoglobulin E (IgE)
3.	Transforming Growth Factors (Transforming Growth Factor)
4.	Glucocorticoids
5.	Dextrans (Dextran)
6.	Dexamethasone (Maxidex)
7.	Corticosterone
8.	Bleomycin (Blenoxane)
9.	Allergens
10.	3- (3- chlorophenoxymethyl)- 1- (tetrahydropyran- 4- yl)- 1H- pyrazolo(3,4- d)pyrimidin- 4- ylamine