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1-(benzofurazan-5-ylcarbonyl)piperidine

an allosteric modulator of AMPA receptors

Also Known As:

5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole; CX-691; Org 24448; farampator

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - Oxadiazoles: 146
        1-(benzofurazan-5-ylcarbonyl)piperidine: 2
  - Piperidines: 17
    - 1-(benzofurazan-5-ylcarbonyl)piperidine: 2

Experts

1.	Shahid, Mohammed: 2 articles (05/2012 - 08/2005)
2.	Jardemark, Kent: 1 article (05/2012)
3.	Malmerfelt, Anna: 1 article (05/2012)
4.	Marcus, Monica M: 1 article (05/2012)
5.	Svensson, Torgny H: 1 article (05/2012)
6.	Henry, Brian: 1 article (08/2005)
7.	Hill, David R: 1 article (08/2005)
8.	Horsburgh, Karen: 1 article (08/2005)
9.	Jordan, Graeme R: 1 article (08/2005)
10.	McCulloch, James: 1 article (08/2005)

Related Diseases

1.

Schizophrenia (Dementia Praecox)

08/01/2005 - "These data demonstrate that both Org 26576 and Org 24448 produce dose-dependent AMPA receptor mediated increases in LCGU and provide an anatomical basis suggestive that these drugs may be of use in the treatment of conditions such as depression or schizophrenia."
05/01/2012 - "The α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor positive allosteric modulators (AMPA-PAMs), Org 24448 and Org 26576, and the glycine transporter-1 (GlyT-1) inhibitor Org 25935 are developed for treatment of schizophrenia. "

Related Drugs and Biologics

1.	AMPA Receptors (AMPA Receptor)
2.	Org 26576
3.	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)
4.	Glycine (Aminoacetic Acid)
5.	N- methyl- N- (6- methoxy- 1- phenyl- 1,2,3,4- tetrahydronaphthalen- 2- ylmethyl)aminomethylcarboxylic acid
6.	propionic acid (potassium propionate)