N14-desacetoxytubulysin H
structure in first source
Also Known As:
WZY-III-63C; desacetoxytubulysin H
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Bio-Agent Context: Research Results
Experts
Related Diseases
| 1. | Neoplasms (Cancer)
12/22/2021
- " Synthesis of fragments, Tuv, Tup, and Tut can be accomplished by adopting appropriate strategies such as Manganese-mediated synthesis, Ireland-Claisen rearrangement, Mukaiyama aldol reaction, and Mannich process etc. Tubulysin B, D, U, V, and N14-desacetoxytubulysin H have been prepared through Mitsunobu reaction, tert-butanesulfinamide method, Tandem reaction, aza-Barbier reaction, Evans aldol reaction, and C-H activation strategies etc. The remarkable anticancer potential of tubulysins toward a substantiate target make them prominent leads for developing novel drugs against multidrug-resistant cancers."
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