HO-3538

a superoxide dismutase-mimetic permeability transition inhibitor agent that protects ischemic heart by inhibiting both apoptotic and necrotic cell death; structure in first source

Also Known As:

2-methyl-3-(3,5-diiodo-4-(2-N-ethyl,N-(1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-ylmethyl)ethyl)oxybenzoyl)benzofurane .2HCl salt

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzofurans: 26
      - Amiodarone: 5571
        HO-3538: 1

Experts

1.	Bognar, Balazs: 1 article (09/2006)
2.	Bognar, Zita: 1 article (09/2006)
3.	Gallyas, Ferenc: 1 article (09/2006)
4.	Hanto, Katalin: 1 article (09/2006)
5.	Hideg, Kalman: 1 article (09/2006)
6.	Kalai, Tamas: 1 article (09/2006)
7.	Mark, Laszlo: 1 article (09/2006)
8.	Palfi, Anita: 1 article (09/2006)
9.	Radnai, Balazs: 1 article (09/2006)
10.	Sarszegi, Zsolt: 1 article (09/2006)

Related Diseases

1.	Infarction (Infarctions) 09/01/2006 - "Furthermore, HO-3538 significantly enhanced the recovery of mitochondrial energy metabolism and functional cardiac parameters; decreased infarct size, lipid peroxidation, and protein oxidation; and suppressed necrotic as well as apoptotic cell death pathways in Langendorff-perfused hearts. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)