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lactucin

structure in first source

Also Known As:

11beta,13-dihydrolactucin

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - Phorbols: 26
        lactucin: 3
    - Sesquiterpenes: 1370
      - lactucin: 3
- Lactones: 1549
  - lactucin: 3

Experts

1.	Jang, Ji Hoon: 1 article (10/2021)
2.	Jung, Chuleui: 1 article (10/2021)
3.	Kim, Joo-Young: 1 article (10/2021)
4.	Lee, Tae-Jin: 1 article (10/2021)
5.	Park, Cho-Young: 1 article (10/2021)
6.	Sohn, Ho-Yong: 1 article (10/2021)
7.	Song, In-Hwan: 1 article (10/2021)
8.	Sung, Eon-Gi: 1 article (10/2021)
9.	Cai, Guo He: 1 article (01/2020)
10.	Chen, Yan: 1 article (01/2020)

Related Diseases

1.	Leukemia 10/01/2021 - "A recent study reported that lactucin could induce apoptosis in leukemia cells. "
2.	Kidney Neoplasms (Kidney Cancer) 10/01/2021 - "Therefore, in this study, we aimed to investigate the direct effect and underlying mechanism of action of lactucin on renal cancer cells. " 10/01/2021 - "Western blotting, reverse transcription polymerase chain reaction, and protein stability analyses were performed to analyze the effect of lactucin on the expression of apoptosis-related proteins such as B-cell lymphoma 2 (BCL-2) and CFLAR (CASP8 and FADD like apoptosis regulator) long isoform (CFLARL) in Caki-1 human renal cancer cells. "
3.	B-Cell Lymphoma (Lymphoma, B Cell) 10/01/2021 - "Western blotting, reverse transcription polymerase chain reaction, and protein stability analyses were performed to analyze the effect of lactucin on the expression of apoptosis-related proteins such as B-cell lymphoma 2 (BCL-2) and CFLAR (CASP8 and FADD like apoptosis regulator) long isoform (CFLARL) in Caki-1 human renal cancer cells. "
4.	Obesity 01/01/2020 - "Together, our results provide the indication that lactucin exerts an anti-adipogenesis effect, which may open new therapeutic options for obesity."
5.	Neoplasms (Cancer) 10/29/2022 - "Lactucin, a Bitter Sesquiterpene from Cichorium intybus, Inhibits Cancer Cell Proliferation by Downregulating the MAPK and Central Carbon Metabolism Pathway." 10/29/2022 - "In an activity-based protein profiling (ABPP) analysis of A549 cell's protein lysate using a biotinylated Lactucin probe, we found that Lactucin binds PGM, PKM, and LDHA PDH, four critical enzymes in central carbon metabolism in cancer cells, limiting cancer cells in its growth; thus, Lactucin inhibits cancer cell proliferation by downregulating the MAPK and the Central Carbon Metabolism pathway."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Protein Isoforms (Isoforms)
3.	Sesquiterpenes
4.	Enzymes
5.	Carbon