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ashwagandhanolide

bioactive dimeric thiowithanolide from the roots of Withania somnifera; structure in first source

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Cholestanes
      - Cholestenes
        Ergosterol: 305
        ashwagandhanolide: 1

Related Diseases

1.

Breast Neoplasms (Breast Cancer)

01/01/2022 - "Phytoconstituents of Withania somnifera unveiled Ashwagandhanolide as a potential drug targeting breast cancer: Investigations through computational, molecular docking and conceptual DFT studies."
01/01/2022 - "The molecular docking result showed that among 44 compounds, two of them, Ashwagandhanolide and Withanolide sulfoxide have the potential to inhibit estrogen receptor alpha (ERα), 17-beta-hydroxysteroid -dehydrogenase type 1 (17β-HSD1), topoisomerase II alpha (TOP2A) and p73 tetramerization domain that are expressed during breast cancer. "

Related Drugs and Biologics

1.	Estrogen Receptor alpha
2.	Oxidoreductases (Dehydrogenase)
3.	Type II DNA Topoisomerases (Topoisomerase II)
4.	sulfoxide