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Arg-Pro-Leu-Lys-Pro-Trp

has antihypertensive activity

Also Known As:

RPLKPW peptide; arginyl-prolyl-leucyl-lysyl-prolyl-tryptophan; novokinin

Networked: 5 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Arg-Pro-Leu-Lys-Pro-Trp: 5

Experts

1.	Bhavsar, Riya: 1 article (06/2019)
2.	Kurade, Mangesh: 1 article (06/2019)
3.	Mustafa, S Jamal: 1 article (06/2019)
4.	Patel, Mehaben: 1 article (06/2019)
5.	Ponnoth, Dovenia S: 1 article (06/2019)
6.	Rajalingam, Sahith: 1 article (06/2019)
7.	Grozdanov, P: 1 article (05/2018)
8.	Nenchovska, Z: 1 article (05/2018)
9.	Pechlivanova, D: 1 article (05/2018)
10.	Petrov, K: 1 article (05/2018)

Related Diseases

1.	Hypertension (High Blood Pressure) 06/23/2016 - "Although further studies are needed to determine its effectiveness, the AT2 agonist novokinin may be a novel agent that is promising in terms of protective effects for the treatment of hypertension." 06/23/2016 - "The effects of novokinin, an AT2 agonist, on blood pressure, vascular responses, and levels of ADMA, NADPH oxidase, and Rho kinase in hypertension induced by NOS inhibition and salt." 06/23/2016 - "The effects of AT2 receptor agonist novokinin on blood pressure, eNOS, NADPH oxidase, protein arginine methyltransferases (PRMTs), and Rho kinase in hypertension were investigated. "
2.	Hyperalgesia 05/01/2018 - "Novokinin infusion increased water intake, diuresis, and mortality rate, decreased food intake, exacerbated diabetes-induced hyperalgesia, and provoked anxiety-like behavior but improved spatial memory in diabetic rats. "
3.	Asthma (Bronchial Asthma) 06/01/2019 - "In this study, we investigated effects of AT1 receptor antagonist losartan, novel AT2 receptor agonist novokinin and AT2 receptor antagonist PD 123319 in a mouse model of asthma. "
4.	Ulcer 11/01/2016 - "Meanwhile, pre-treatment with novokinin at doses of 10, 50, and 100 nmol/rat significantly reduced the alcohol-induced gastric mucosal injury compared to the ulcer-control group, which was inhibited by indomethacin (10 mg/kg). "
5.	Diabetes Mellitus 05/01/2018 - "Intracerebroventricular infusion of angiotensin AT2 receptor agonist novokinin aggravates some diabetes-mellitus-induced alterations in Wistar rats."

Related Drugs and Biologics

1.	Losartan (Cozaar)
2.	PD 123319
3.	rho-Associated Kinases
4.	Type 2 Angiotensin Receptor
5.	NADPH Oxidases (NAD(P)H oxidase)
6.	Salts
7.	Proteins (Proteins, Gene)
8.	Methyltransferases
9.	Indomethacin (Indometacin)
10.	Arginine (L-Arginine)

Related Therapies and Procedures

1.	Intraventricular Infusions