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S-(2-succinyl)cysteine

structure in first source

Also Known As:

2-succinocysteine; S-(2-succino)cysteine; S-(2-succinyl)Cys

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfhydryl Compounds: 4168
    - Cysteine: 6760
      - S-(2-succinyl)cysteine: 6
  - Sulfur Amino Acids: 221
    - Cysteine: 6760
      - S-(2-succinyl)cysteine: 6
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Sulfur Amino Acids: 221
    - Cysteine: 6760
      - S-(2-succinyl)cysteine: 6
  - Neutral Amino Acids: 200
    - Cysteine: 6760
      - S-(2-succinyl)cysteine: 6

Experts

1.	Frizzell, Norma: 2 articles (01/2016 - 02/2012)
2.	Hodgson, Anjelica: 1 article (10/2021)
3.	Zyla, Roman E: 1 article (10/2021)
4.	Bando, Hironori: 1 article (01/2020)
5.	Chihara, Kazuo: 1 article (01/2020)
6.	Fujisawa, Masato: 1 article (01/2020)
7.	Fukuoka, Hidenori: 1 article (01/2020)
8.	Iguchi, Genzo: 1 article (01/2020)
9.	Matsumoto, Ryusaku: 1 article (01/2020)
10.	Mukai, Miki: 1 article (01/2020)

Related Diseases

1.	Chronic Renal Insufficiency 03/01/2023 - "This study demonstrates that mitochondrial metabolic disorders contribute to impaired kidney function, and that measuring blood S-(2-succinyl)cysteine levels may be a minimally invasive way to evaluate the metabolic change in chronic kidney disease." 03/01/2023 - "While the S-(2-succinyl)cysteine and AGEs levels were significantly increased in accordance with the rising chronic kidney disease severity, they were significantly decreased after transplantation. " 03/01/2023 - "Here, we quantified the concentration of fumarate, the free form of S-(2-succinyl)cysteine, and advanced glycation end-products, including N ε-(carboxymethyl)lysine and N δ-(5-hydro-5-methyl-4-imidazolone-2-yl)-ornithine, in the serum of chronic kidney disease patients, using liquid chromatography-tandem mass spectrometry and an enzymatic assay. "
2.	Leiomyoma (Uterine Fibroids) 11/01/2023 - "We performed immunohistochemistry on whole sections of patients with uterine leiomyoma to evaluate for both FH and 2-succinocysteine (2SC) expression. " 01/01/2016 - "Immunohistochemistry (IHC) for 2-succinocysteine (2SC) and FH has also been shown to correlate well with FH gene mutation status in RCC and uterine leiomyomas. " 01/01/2016 - "Immunohistochemistry for 2-Succinocysteine (2SC) and Fumarate Hydratase (FH) in Cutaneous Leiomyomas May Aid in Identification of Patients With HLRCC (Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome)."
3.	Leiomyomatosis 01/01/2016 - "Immunohistochemistry for 2-Succinocysteine (2SC) and Fumarate Hydratase (FH) in Cutaneous Leiomyomas May Aid in Identification of Patients With HLRCC (Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome)."
4.	Obesity 02/01/2012 - "Tissue distribution of S-(2-succino)cysteine (2SC), a biomarker of mitochondrial stress in obesity and diabetes."
5.	Neoplasms (Cancer) 10/01/2021 - "FH-deficient neoplasms can present with characteristic morphological features that raise suspicion for FH alterations and also frequently demonstrate loss of FH immunoreactivity and intracellular accumulation of 2-succinocysteine, also detected by immunohistochemistry."

Related Drugs and Biologics

1.	Advanced Glycation End Products
2.	Biomarkers (Surrogate Marker)
3.	Proteins (Proteins, Gene)
4.	Fumarates
5.	Fumarate Hydratase (Fumarase)
6.	N(6)-carboxymethyllysine (carboxymethyllysine)

Related Therapies and Procedures

1.	Transplantation