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CB694

antimitotic with antitumor activities; structure in first source

Also Known As:

1-(5-chloro-2-methoxybenzoyl)-4-(3-chlorophenyl)piperazine

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - CB694: 1

Experts

1.	Hamel, Ernest: 1 article (02/2006)
2.	Mooberry, Susan L: 1 article (02/2006)
3.	Polin, Lisa A: 1 article (02/2006)
4.	Randall-Hlubek, Deborah A: 1 article (02/2006)
5.	Weiderhold, Kimberly N: 1 article (02/2006)

Related Diseases

1.

Neoplasms (Cancer)

02/15/2006 - "The efficacy of CB694 against a syngeneic murine transplantable solid tumor, Mammary 16/C, was also evaluated. "
02/15/2006 - "The compound, designated CB694, caused inhibition of proliferation of a wide range of cancer cell lines, with an average IC50 of 85 nM. A multidrug-resistant cell line was sensitive to inhibition by CB694, suggesting that this compound is a poor substrate for transport by P-glycoprotein. "

Related Drugs and Biologics

1.	Member 1 Subfamily B ATP Binding Cassette Transporter