4,4',4''- (4- propyl- ((1)H)- pyrazole- 1,3,5- triyl) tris-phenol

an estrogen receptor modulator

Also Known As:

1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole; 1,3,5-trisHOPhPP; 4,4',4''-(4-propyl-(1H)-pyrazole-1,3,5-triyl)trisphenol; PPT cpd; PPT trisphenol compound; PPTP cpd; phenol, 4,4',4''-(4-propyl-1H-pyrazole-1,3,5-triyl)tris-; propyl pyrazole triol; propyl-(1H)-pyrazole-1,3,5-triyltrisphenol; propylpyrazole triol

Networked: 19 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chaudry, Irshad H: 3 articles (11/2008 - 06/2006)
2.	Khaksari, Mohammad: 2 articles (01/2021 - 09/2013)
3.	Li, Jing: 2 articles (05/2007 - 09/2006)
4.	McMurray, Robert W: 2 articles (05/2007 - 09/2006)
5.	Choudhry, Mashkoor A: 2 articles (09/2006 - 06/2006)
6.	Hildebrand, Frank: 2 articles (09/2006 - 06/2006)
7.	Hubbard, William J: 2 articles (09/2006 - 06/2006)
8.	Pape, Hans-Christoph: 2 articles (09/2006 - 06/2006)
9.	Asadikaram, Gholamreza: 1 article (01/2021)
10.	Brooke Davis, Jordan: 1 article (01/2021)

Related Diseases

1.	Wounds and Injuries (Trauma) 09/01/2006 - "To test these hypotheses, female B57BL/J6 mice received E2 (50 microg/25 g) or vehicle after trauma-hemorrhage and female 129 Sve ER-beta-/- transgenic mice and ovariectomized wild-type mice received E2 or ER-alpha agonist propyl pyrazole triol (50 microg/25 g) after trauma-hemorrhage. " 06/01/2006 - "Female B57BL/J6 ER-beta(-/-) transgenic mice [knockout (KO)] and corresponding ovariectomized wild-type (WT) mice were subjected to laparotomy and hemorrhagic shock (35.0+/-5.0 mmHg for 90 min) and treated with E2 (50 microg/25 g) or ER-alpha agonist propyl pyrazole triol (PPT; 50 microg/25 g) following trauma-hemorrhage. " 11/01/2008 - "To study this, the dose-dependent effects of estrogen, propylpyrazole triol (ER-alpha agonist), and diarylpropionitrile (DPN; ER-beta agonist) on heart performance (+dP/dt) were determined in sham rats and in experimental animals at the time of maximal bleedout (MBO) or at 2 h after trauma-hemorrhage. " 09/01/2013 - "Adult female rats were ovariectomized and distributed among the following 9 groups: (i) sham trauma, (ii) TBI (Marmarou's method), (iii) vehicle (dimethylsulfoxide) treated, (iv) estrogen (E2) treated, (v) progesterone (P) treated, (vi) treated with E2+P, (vii) propylpyrazole triol (PPT) treated, (viii) diarylpropionitrile (DPN) treated, and (ix) control. "
2.	Hemorrhage 09/01/2006 - "To test these hypotheses, female B57BL/J6 mice received E2 (50 microg/25 g) or vehicle after trauma-hemorrhage and female 129 Sve ER-beta-/- transgenic mice and ovariectomized wild-type mice received E2 or ER-alpha agonist propyl pyrazole triol (50 microg/25 g) after trauma-hemorrhage. " 06/01/2006 - "Female B57BL/J6 ER-beta(-/-) transgenic mice [knockout (KO)] and corresponding ovariectomized wild-type (WT) mice were subjected to laparotomy and hemorrhagic shock (35.0+/-5.0 mmHg for 90 min) and treated with E2 (50 microg/25 g) or ER-alpha agonist propyl pyrazole triol (PPT; 50 microg/25 g) following trauma-hemorrhage. " 11/01/2008 - "To study this, the dose-dependent effects of estrogen, propylpyrazole triol (ER-alpha agonist), and diarylpropionitrile (DPN; ER-beta agonist) on heart performance (+dP/dt) were determined in sham rats and in experimental animals at the time of maximal bleedout (MBO) or at 2 h after trauma-hemorrhage. "
3.	Breast Neoplasms (Breast Cancer) 10/06/2023 - "In the present study, 3D microtissues formed by MCF-7 breast cancer cells were exposed to the model EDCs estradiol (E2) and propyl pyrazole triol (PPT). " 10/11/2019 - "Here we demonstrated that 17β-estradiol (E2), as well as xenoestrogen bisphenol A and ERα agonist propyl pyrazole triol, led to HSF1 phosphorylation on S326 in ERα positive but not in ERα-negative mammary breast cancer cells. " 01/01/2016 - "To investigate each receptor's role in proliferation, transcriptional activation, and protein phosphorylation in breast cancer cells (MCF-7), we employed selective agonists for ESR1 propyl-pyrazole-triol (PPT), ESR2 diarylpropionitrile (DPN), and GPER (G-1) and also determined the impact of xenoestrogens bisphenol-A (BPA) and genistein on these effects. "
4.	Traumatic Brain Injuries (Traumatic Brain Injury) 01/01/2021 - "The present study aimed to examine whether the attenuation of estrogen receptor expression is prevented by propyl pyrazole triol (PPT), an agonist for estrogen receptor α (ERα) or and diarypropiolnitrile (DPN), an agonist for estrogen receptor β (ERβ) after traumatic brain injury (TBI). "
5.	Endometrial Neoplasms (Endometrial Cancer) 01/01/2013 - "Here, employing ERα-negative Hec50 endometrial cancer cells, we demonstrate that GPER mediates estrogen-stimulated activation of ERK and PI3K via matrix metalloproteinase activation and subsequent transactivation of the EGFR and that ER-targeted therapeutic agents (4-hydroxytamoxifen, ICI182,780/fulvestrant, and Raloxifene), the phytoestrogen genistein, and the "ERα-selective" agonist propylpyrazole triol also function as GPER agonists. "

Related Drugs and Biologics

1.	NAD (NADH)
2.	2,3-bis(4-hydroxyphenyl)-propionitrile
3.	Estrogens (Estrogen)
4.	salicylhydroxamic acid (SHAM)
5.	Estrogen Receptors
6.	Estradiol (Delestrogen)
7.	Estrogen Receptor alpha
8.	Estrogen Receptor beta
9.	Genistein
10.	Fulvestrant (Faslodex)

Related Therapies and Procedures

1.	Intraventricular Infusions
2.	Stents
3.	Laparotomy