omiganan pentahydrochloride

a cationic peptide with antibacterial activity

Also Known As:

ILRWPWWPWRRK-amide; MBI-226; L-Lysinamide, L-isoleucyl-L-leucyl-L-arginyl-L-tryptophyl-L-prolyl-L-tryptophyl-L-tryptophyl-L-prolyl-L-tryptophyl-L-arginyl-L-arginyl-, hydrochloride (1:5)

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Pore Forming Cytotoxic Proteins
      - Antimicrobial Cationic Peptides: 414
        omiganan pentahydrochloride: 6
- Peptides: 82426
  - Antimicrobial Peptides: 3727
    - Antimicrobial Cationic Peptides: 414
      - omiganan pentahydrochloride: 6
  - Antimicrobial Cationic Peptides: 414
    - omiganan pentahydrochloride: 6

Experts

1.	Fritsche, Thomas R: 2 articles (05/2008 - 03/2008)
2.	Jones, Ronald N: 2 articles (05/2008 - 03/2008)
3.	Rhomberg, Paul R: 2 articles (05/2008 - 03/2008)
4.	Sader, Helio S: 2 articles (05/2008 - 03/2008)
5.	Cong, Tian-Xin: 1 article (07/2019)
6.	Hao, Dan: 1 article (07/2019)
7.	He, Gu: 1 article (07/2019)
8.	Jiang, Xian: 1 article (07/2019)
9.	Li, Xiao-Hua: 1 article (07/2019)
10.	Wen, Xiang: 1 article (07/2019)

Related Diseases

1.	Sepsis (Septicemia) 08/01/2003 - "In September 2000, a phase III trial of MBI-226 for the potential prevention of catheter-related bloodstream infections was initiated."
2.	Catheter-Related Infections 05/01/2008 - "Antimicrobial activity of omiganan pentahydrochloride tested against contemporary bacterial pathogens commonly responsible for catheter-associated infections." 03/01/2008 - "Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter-associated infections." 05/01/2008 - "Omiganan pentahydrochloride is a cidal cationic peptide with a broad antimicrobial spectrum, including yeast, currently in development as a topical agent for the prevention of catheter-associated infections. " 11/01/2009 - "Omiganan pentahydrochloride is a novel, synthetic, cationic, antimicrobial peptide that is being developed for the prevention of catheter-related infections and the treatment of acne and rosacea. "
3.	Acne Vulgaris 11/01/2009 - "Omiganan pentahydrochloride is a novel, synthetic, cationic, antimicrobial peptide that is being developed for the prevention of catheter-related infections and the treatment of acne and rosacea. " 11/01/2010 - "New active agents such as topical antimicrobial peptides, inhibitors of ectopeptidase, omiganan pentahydrochloride, antisense oligonucleotides, lauric acid are many original ways to explore for the treatment of acne. " 07/01/2019 - "New approaches including peroxisome proliferator-activated receptor γ modifier, melanocortin receptor antagonists, epigallocatechin-3-gallate, metformin, olumacostat glasaretil, stearoyl-CoA desaturase inhibitor omiganan pentahydrochloride, KDPT, afamelanotide, apremilast and biologics have been developed as promising treatments for acne vulgaris. "
4.	Rosacea (Acne Rosacea) 11/01/2009 - "Omiganan pentahydrochloride is a novel, synthetic, cationic, antimicrobial peptide that is being developed for the prevention of catheter-related infections and the treatment of acne and rosacea. "
5.	Infections 08/01/2003 - "Micrologix and Fujisawa are developing a gel formulation of MBI-226 for the potential treatment and prevention of various infections caused by both antibiotic-resistant and -sensitive bacteria. "

Related Drugs and Biologics

1.	Peroxisome Proliferator-Activated Receptors (PPAR)
2.	Melanocortin Receptors (Melanocortin Receptor)
3.	Antimicrobial Cationic Peptides
4.	Antisense Oligonucleotides
5.	Stearoyl-CoA Desaturase
6.	Peptides (Polypeptides)
7.	Metformin (Glucophage)
8.	Anti-Bacterial Agents (Antibiotics)
9.	Antimicrobial Peptides
10.	afamelanotide

Related Therapies and Procedures

1.	Catheters