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(P(1)- thymidine- 3'- azido- 2',3'- dideoxyriboside- 5')- P(2)- (9- 2- (phosphonomethoxypropyl)adenine)

structure in first source; heterodinucleotide, consisting of tenofovir and zidovudine chemically coupled together by a phosphate bridge

Also Known As:

AZTpPMPA

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleosides: 50
      - Thymidine: 4460
        Zidovudine: 3074
        (P(1)-thymidine-3'-azido-2',3'-dideoxyriboside-5')-P(2)-(9-2-(phosphonomethoxypropyl)adenine): 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Adenine: 2120
        (P(1)-thymidine-3'-azido-2',3'-dideoxyriboside-5')-P(2)-(9-2-(phosphonomethoxypropyl)adenine): 1
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Dideoxynucleotides: 3
    - (P(1)-thymidine-3'-azido-2',3'-dideoxyriboside-5')-P(2)-(9-2-(phosphonomethoxypropyl)adenine): 1
- Nucleosides: 6847
  - Pyrimidine Nucleosides: 50
    - Thymidine: 4460
      - Zidovudine: 3074
        (P(1)-thymidine-3'-azido-2',3'-dideoxyriboside-5')-P(2)-(9-2-(phosphonomethoxypropyl)adenine): 1
  - Deoxyribonucleosides: 34
    - Thymidine: 4460
      - Zidovudine: 3074
        (P(1)-thymidine-3'-azido-2',3'-dideoxyriboside-5')-P(2)-(9-2-(phosphonomethoxypropyl)adenine): 1
    - Dideoxynucleosides: 27
      - Zidovudine: 3074
        (P(1)-thymidine-3'-azido-2',3'-dideoxyriboside-5')-P(2)-(9-2-(phosphonomethoxypropyl)adenine): 1

Experts

1.	Carnevali, Andrea: 1 article (11/2002)
2.	Casabianca, Anna: 1 article (11/2002)
3.	Franchetti, Palmarisa: 1 article (11/2002)
4.	Magnani, Mauro: 1 article (11/2002)
5.	Orlandi, Chiara: 1 article (11/2002)
6.	Rossi, Luigia: 1 article (11/2002)
7.	Schiavano, Giuditta Fiorella: 1 article (11/2002)
8.	Serafini, Sonja: 1 article (11/2002)

Related Diseases

1.	Disease Progression 11/01/2002 - "C57BL/6 mice infected with the retroviral complex LP-BM5 were used to evaluate the efficacy of AZTpPMPA in inhibiting disease progression. "
2.	Splenomegaly 11/01/2002 - "The results obtained showed that AZTpPMPA is able to reduce lymphoadenopathy (88%), splenomegaly (64%), lymph node BM5 proviral DNA content (49%) and hypergammaglobulinaemia (40%). "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)