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3-bromopropionylamino benzoylurea

structure in first source

Also Known As:

JIMB01

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - 3-bromopropionylamino benzoylurea: 2

Experts

1.	Jiang, Jian-Dong: 2 articles (07/2004 - 05/2003)
2.	Li, Jian-Nong: 2 articles (07/2004 - 05/2003)
3.	Song, Dan-Qing: 2 articles (07/2004 - 05/2003)
4.	Bekesi, George: 1 article (05/2003)
5.	Holland, James F: 1 article (05/2003)
6.	Hu, Qiong-Ying: 1 article (05/2003)
7.	Lin, Yi-He: 1 article (05/2003)
8.	Yin, Lu: 1 article (05/2003)

Related Diseases

1.	Lymphoma (Lymphomas) 07/01/2004 - "[Antitumor mechanism of 3-bromopropionylamino benzoylurea on leukemia and lymphoma]." 07/01/2004 - "To study the antitumor mechanism of 3-bromopropionylamino benzoylurea (JIMB01) on leukemia and lymphoma. "
2.	Leukemia 07/01/2004 - "[Antitumor mechanism of 3-bromopropionylamino benzoylurea on leukemia and lymphoma]." 07/01/2004 - "JIMB01 increased the activities of caspase-3, -8 and -9 in CEM cells; DEVD-fmk, a caspase-3 inhibitor, inhibited the cytotoxicity of JIMB01 in CEM leukemia cells. " 07/01/2004 - "DNA degradation in the form of a multiple-unit DNA ladder was clearly demonstrated in CEM leukemia cells treated with JIMB01 at 0.15 micromol x L(-1) or higher for 24 h using agarose gel electrophoresis. " 07/01/2004 - "To study the antitumor mechanism of 3-bromopropionylamino benzoylurea (JIMB01) on leukemia and lymphoma. "
3.	Neoplasms (Cancer) 05/15/2003 - "Since JIMB01 is a small compound, targets a specific molecule in tumor cells, and has promising activity against human hepatocarcinoma in vivo, we believe JIMB01 merits consideration for further investigation." 07/01/2004 - "The antitumor mechanism of JIMB01 is that JIMB01 may induce tumor cell apoptosis through Bcl-2 phosphorylation and then caspase passway." 05/15/2003 - "Furthermore, in vivo experiments using nude mice showed that intraperitoneal injection of JIMB01 at 15mg/kg (with seven injections at 4-day intervals) significantly inhibited the growth of a human hepatocarcinoma (BEL-7402) by 66% in tumor volume (P=0.01), at least compatible to the inhibition by vincristine (43% inhibition), indicating good bioavailability of the compound in the circulation. "

Related Drugs and Biologics

1.	3-bromopropionylamino benzoylurea
2.	Caspase 3 (Caspase-3)
3.	Caspases
4.	Vincristine (Oncovin)
5.	Sepharose (Agarose)
6.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Injections