HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

Amplex Red

a component of the Amplex Red Hydrogen Peroxide Assay Kit

Also Known As:

10-acetyl-10H-phenoxazine-3,7-diol; 10-acetyl-3,7-dihydroxyphenoxazine; amplex red reagent

Networked: 17 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Oxazines: 9
    - Amplex Red: 17

Experts

1.	Liu, Yitong: 2 articles (05/2017 - 11/2015)
2.	Santillo, Michael F: 2 articles (05/2017 - 11/2015)
3.	Burcus, Niculina I: 1 article (12/2021)
4.	Guo, Siqi: 1 article (12/2021)
5.	Jing, Yu: 1 article (12/2021)
6.	Scott, Megan: 1 article (12/2021)
7.	Semenov, Iurii: 1 article (12/2021)
8.	Fisher, Gordon: 1 article (10/2021)
9.	Garvey, W Timothy: 1 article (10/2021)
10.	Gower, Barbara A: 1 article (10/2021)

Related Diseases

1.	Inflammation (Inflammations) 10/08/2015 - "We synthesized and characterized more than 50 quinazolin-4(1H)-one derivatives and showed that this class of compounds inhibits MPO with IC50 values as low as 100 nM. Representative compounds showed partially reversible inhibition that was competitive with respect to Amplex Red substrate and did not result in the accumulation of MPO Compound II. Members of this group show promise for therapeutic development for the treatment of diseases in which inflammation plays a pathogenic role. "
2.	Neuroblastoma 05/01/2017 - "In this study, a fluorescent method using Amplex Red (10-acetyl-3,7-dihydroxyphenoxazine) and the Ellman absorbance method were both developed in a homogenous format using a human neuroblastoma cell line (SH-SY5Y). " 11/01/2015 - "For the second application, Amplex Red assay was used to measure AChE inhibition potency in a human neuroblastoma cell line (SH-SY5Y), which is important for assessing pharmacological and toxicological potential of AChE inhibitors including drugs, phytochemicals, and pesticides. "
3.	Wounds and Injuries (Trauma) 11/07/2020 - "In vivo studies carried out in diabetic mice with impaired wounds also displayed a visible change in color of the mats infused with Amplex red within 24 hours. "
4.	Hypoxia (Hypoxemia) 10/10/2008 - "ROS production, tracked using Fe(2+)-catalyzed, H(2)O(2)-dependent H(2)DCF oxidation or Amplex Red, was similar during normoxia and hypoxia but markedly increased during reoxygenation, in proportion to the duration of hypoxia. " 10/01/2015 - "Compared with hypoxic control mice, MCAT mice developed smaller hypoxia-induced increases in RVSP, α-SMA staining, extracellular H(2)O(2) (Amplex Red), Nox2 and Nox4 (qRT-PCR and Western blot), or cyclinD1 and PCNA (Western blot). " 06/01/2008 - "Using dihydrodichlorofluorescein diacetate, dihydroethidium, and Amplex Red (Molecular Probes; Eugene, OR), we estimated ROS generation by confluent primary cultures of HPASMC and human coronary artery smooth-muscle cells (HCASMC) under normoxia (20%) and acute hypoxia (5%). "
5.	Muscular Atrophy (Muscle Atrophy) 01/02/2009 - "In support of this, muscle atrophy and the Amplex Red signal are inhibited in caloric restricted mice and in transgenic mice that overexpress the lipid hydroperoxide-detoxifying enzyme glutathione peroxidase 4. Finally, we propose that cytosolic phospholipase A2 may be a potential source of these hydroperoxides."

Related Drugs and Biologics

1.	methylallyl trisulfide (MATS)
2.	Indicators and Reagents (Reagents)
3.	dihydroethidium
4.	Phytochemicals
5.	Phospholipases A2 (Phospholipase A2)
6.	Proliferating Cell Nuclear Antigen (PCNA)
7.	Molecular Probes (Molecular Probe)
8.	Lipid Peroxides
9.	Hydrogen Peroxide (Hydroperoxide)
10.	Horseradish Peroxidase

Related Therapies and Procedures

1.	Caloric Restriction
2.	Resuscitation