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N-methylvaline

Also Known As:

3-methyl-2-(methylamino)butanoic acid; MeVal

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Branched-Chain Amino Acids: 2289
    - Valine: 1999
      - N-methylvaline: 6
  - Essential Amino Acids: 1152
    - Valine: 1999
      - N-methylvaline: 6

Experts

1.	Fang, James C: 3 articles (01/2022 - 01/2020)
2.	Hess, Rachel: 3 articles (01/2022 - 01/2020)
3.	Lyons, Ann: 3 articles (01/2022 - 01/2020)
4.	Piccini, Jonathan P: 3 articles (01/2022 - 01/2020)
5.	Spertus, John A: 3 articles (01/2022 - 01/2020)
6.	Stehlik, Josef: 3 articles (01/2022 - 01/2020)
7.	Steinberg, Benjamin A: 3 articles (01/2022 - 01/2020)
8.	Bunch, T Jared: 2 articles (01/2022 - 12/2020)
9.	Greene, Tom: 2 articles (01/2022 - 12/2020)
10.	Zhang, Mingyuan: 2 articles (01/2022 - 12/2020)

Related Diseases

1.	Atrial Fibrillation 12/01/2020 - "Patient-reported outcomes and subsequent management in atrial fibrillation clinical practice: Results from the Utah mEVAL AF program." 01/01/2020 - "Systematic collection of patient-reported outcomes in atrial fibrillation: feasibility and initial results of the Utah mEVAL AF programme." 01/01/2022 - "Quantifying the Impact of Atrial Fibrillation on Heart Failure-Related Patient-Reported Outcomes in the Utah mEVAL Program."
2.	Neoplasms (Cancer) 10/10/2002 - "Cyclic undecapeptide cyclo-[MeBmt(1)-Abu(2)-MeGly(3)-MeLeu(4)-Val(5)-MeLeu(6)-Ala(7)-D-Ala(8)-MeLeu(9)-MeLeu(10)-MeVal(11)], the immunosuppressive and antifungal antibiotic cyclosporin A (CsA), was reported to interfere with the MDR1 P-glycoprotein (Pgp), a transmembranous adenosine 5'-triphosphate binding cassette (ABC) transporter with phospholipid flippase or "hydrophobic vacuum cleaner" properties that mediate multidrug resistance (MDR) of cancer cells. "
3.	Memory Disorders (Memory Loss) 10/24/2003 - "Administration of CyA (20 nM) and FK506, but not [MeVal(4)]CyA, in the right hemisphere leads to a transient period of memory loss from 10-20 min post-training. " 10/24/2003 - "CyA (5 nM and 20 nM), which inhibits both PP2B and PPIase activity, causes permanent memory loss from 60 min post-training when injected into the left hemisphere, an effect also observed following administration of FK506 (20 nM), which also inhibits PP2B and PPIase activity, and [MeVal(4)]CyA (5 nM), which inhibits PPIase activity but not PP2B activity. "
4.	Heart Failure 01/01/2022 - "Quantifying the Impact of Atrial Fibrillation on Heart Failure-Related Patient-Reported Outcomes in the Utah mEVAL Program."
5.	Body Weight (Weight, Body) 01/01/2013 - "Pah(enu2) and control mice were intraperitoneally administered (500-750 mg/kg body weight, once daily; standard 19% protein diet) AIB, methyl AIB (MAIB), isovaline, and two MAIB analogs, 2-methyl-2-(methylamino)butanoic (MeVal) and 3-methyl-2-(methylamino)pentanoic (MePent) acids for one week, followed by brain and blood isolation for amino acid analyses using UPLC. "

Related Drugs and Biologics

1.	Member 1 Subfamily B ATP Binding Cassette Transporter
2.	Peptidylprolyl Isomerase (Prolyl Isomerase)
3.	ATP-Binding Cassette Transporters (ABC Transporters)
4.	Cyclosporine (Ciclosporin)
5.	Tacrolimus (Prograf)
6.	Proteins (Proteins, Gene)
7.	Phospholipids (Phosphatides)
8.	Anti-Bacterial Agents (Antibiotics)
9.	Amino Acids
10.	Adenosine (Adenocard)