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SAG compound

an Hh pathway agonist that binds smoothened protein; structure in first source

Also Known As:

SAG 1.1; Smoothened Agonist (SAG)

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Díaz-Nido, Javier: 1 article (04/2022)
2.	Giménez-Cassina, Alfredo: 1 article (04/2022)
3.	Loria, Frida: 1 article (04/2022)
4.	Vicente-Acosta, Andrés: 1 article (04/2022)
5.	Chavali, Manideep: 1 article (12/2021)
6.	Franklin, Robin J M: 1 article (12/2021)
7.	Gonzalez, Fernando: 1 article (12/2021)
8.	Gonzalez, Ginez: 1 article (12/2021)
9.	Kodali, Srikirti: 1 article (12/2021)
10.	Larpthaveesarp, Amara: 1 article (12/2021)

Related Diseases

1.	Down Syndrome (Down's Syndrome) 12/01/2021 - "Previous studies have demonstrated beneficial effects of small molecule Shh-Smoothened agonist (SAG) against neonatal cerebellar injury and it improves Down syndrome-related brain structural deficits in mice. "
2.	Polydactyly (Polydactylism) 01/01/2017 - "Preaxial polydactyly following early gestational exposure to the smoothened agonist, SAG, in C57BL/6J mice." 01/01/2019 - "To determine if there is a correlation between preaxial polydactyly and radial aplasia, we induced ectopic Sonic hedgehog signalling during chicken limb development with application of a smoothened-agonist (SAG) or retinoic acid. "
3.	Bone Fractures (Bone Fracture) 10/28/2016 - "Here we examined therapeutic effects of local and one shot-administration of the Hh agonist known as smoothened agonist (SAG) on bone fracture healing in a mouse model. "
4.	Mitochondrial Diseases (Mitochondrial Disease) 04/12/2022 - "The smoothened agonist SAG reduces mitochondrial dysfunction and neurotoxicity of frataxin-deficient astrocytes."
5.	Medulloblastoma 01/01/2020 - "Medulloblastoma cells were treated for 5.0 and 15 min with Smoothened Agonist (SAG) to induce and with vismodegib to inhibit the HH pathway. "

Related Drugs and Biologics

1.	cyclopamine
2.	Therapeutic Uses
3.	Tretinoin (Retinoic Acid)
4.	Frataxin
5.	HhAntag691