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saprirearine

a tricyclic diterpene from the roots of Salvia prionitis (Labiatae); structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - saprirearine: 1

Experts

1.	Jiang, Aixia: 1 article (05/2022)
2.	Yu, Kun: 1 article (05/2022)
3.	Zhang, Dongying: 1 article (05/2022)
4.	Zhang, Gang: 1 article (05/2022)
5.	Zhang, Xiwen: 1 article (05/2022)

Related Diseases

1.	Mitochondrial Diseases (Mitochondrial Disease) 05/26/2022 - "Meanwhile, saprirearine was found to attenuate mitochondrial dysfunction by inhibiting calcium overload, collapse of the mitochondrial membrane potential, and opening of the mitochondrial permeability transition pore. "
2.	Myocardial Infarction 05/26/2022 - "These findings can provide evidence for the discovery of new therapies targeting myocardial infarction and the application of saprirearine in clinical practice." 05/26/2022 - "To find a novel therapy for myocardial infarction, we have evaluated saprirearine, a natural diterpenoid, using H9c2 cardiomyocytes injured by hypoxia/reoxygenation and explored the possible mechanisms. "
3.	Hypoxia (Hypoxemia) 05/26/2022 - "Saprirearine protects H9c2 cardiomyocytes against hypoxia/reoxygenation-induced apoptosis by activating Nrf2." 05/26/2022 - "Additionally, saprirearine inactivated cysteinyl aspartate-specific proteinase-3, the up-regulated B-cell lymphoma-2 and down-regulated Bcl-2-associated X protein, to inhibit hypoxia/reoxygenation-induced apoptosis. " 05/26/2022 - "To find a novel therapy for myocardial infarction, we have evaluated saprirearine, a natural diterpenoid, using H9c2 cardiomyocytes injured by hypoxia/reoxygenation and explored the possible mechanisms. " 05/26/2022 - "And oxidative stress resulting from hypoxia/reoxygenation was ameliorated by saprirearine through the reduction of reactive oxygen species and malondialdehyde as well as activation of superoxide dismutase and catalase. "

Related Drugs and Biologics

1.	bcl-2-Associated X Protein (bcl 2 Associated X Protein)
2.	Reactive Oxygen Species (Oxygen Radicals)
3.	Superoxide Dismutase
4.	Malondialdehyde (Propanedial)
5.	Diterpenes
6.	Catalase
7.	Calcium
8.	Aspartic Acid (Aspartate)
9.	Mitochondrial Permeability Transition Pore

Related Therapies and Procedures

1.	Therapeutics