3beta-hydroxysterol delta24-reductase

mutations in the gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis; catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis; involved in resistance to neurodegeneration and oxidative stress in Alzheimer's disease; DIMINUTO/DWARF1 homolog; RefSeq NM_014762 (human); NM_053272 (mouse)

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Campi, Valentina: 1 article (06/2005)
2.	Chiodini, Elena: 1 article (06/2005)
3.	Daniotti, Maria: 1 article (06/2005)
4.	Di Stasi, Delia: 1 article (06/2005)
5.	Fiorentini, Silvia: 1 article (06/2005)
6.	Greeve, Isabell: 1 article (06/2005)
7.	Pierotti, Marco A: 1 article (06/2005)
8.	Prinetti, Alessandro: 1 article (06/2005)
9.	Ranzani, Tiziana: 1 article (06/2005)
10.	Rivoltini, Licia: 1 article (06/2005)

Related Diseases

1.	Neoplasms (Cancer) 06/10/2005 - "The DHCR24 gene encoding for the 3beta-hydroxysterol delta24-reductase, an oxidoreductase involved in cholesterol biosynthesis, was isolated by subtractive hybridization as highly expressed in a short-term melanoma cell line derived from a cutaneous metastases (S/M2) compared to that obtained from the autologous primary tumor (S/P). "
2.	Neoplasm Metastasis (Metastasis) 06/10/2005 - "The DHCR24 gene encoding for the 3beta-hydroxysterol delta24-reductase, an oxidoreductase involved in cholesterol biosynthesis, was isolated by subtractive hybridization as highly expressed in a short-term melanoma cell line derived from a cutaneous metastases (S/M2) compared to that obtained from the autologous primary tumor (S/P). "
3.	Melanoma (Melanoma, Malignant) 06/10/2005 - "The DHCR24 gene encoding for the 3beta-hydroxysterol delta24-reductase, an oxidoreductase involved in cholesterol biosynthesis, was isolated by subtractive hybridization as highly expressed in a short-term melanoma cell line derived from a cutaneous metastases (S/M2) compared to that obtained from the autologous primary tumor (S/P). "
4.	Desmosterolosis 10/01/2001 - "Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis." 10/01/2001 - "Patients with desmosterolosis have elevated levels of the cholesterol precursor desmosterol, in plasma, tissue, and cultured cells; this abnormality suggests a deficiency of the enzyme 3beta-hydroxysterol Delta24-reductase (DHCR24), which, in cholesterol biosynthesis, catalyzes the reduction of the Delta24 double bond of sterol intermediates. "

Related Drugs and Biologics

1.	Cholesterol
2.	Sterols
3.	Oxidoreductases (Dehydrogenase)
4.	Enzymes
5.	Desmosterol