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17- cyclopropylmethyl- 6,7- didehydro- 4,5- epoxy- 5'- guanidinyl- 3,14- dihydroxyindolo(2',3'- 6,7)morphinan

structure in first source

Also Known As:

17-cyclopropylmethyl-DEGDM; 5'-GNTI compound; 5'-guanidinonaltrindole; GNTI compound

Networked: 6 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Guanidines: 29
    - 17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-5'-guanidinyl-3,14-dihydroxyindolo(2',3'-6,7)morphinan: 6
Heterocyclic Compounds: 198
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Phenanthrenes: 27
    - Morphinans: 33
      - 17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-5'-guanidinyl-3,14-dihydroxyindolo(2',3'-6,7)morphinan: 6

Experts

1.	Carlson, Erika R: 1 article (05/2021)
2.	Gregory-Flores, Adriana: 1 article (05/2021)
3.	Jackson, Shelley N: 1 article (05/2021)
4.	Koob, George F: 1 article (05/2021)
5.	Marchette, Renata C N: 1 article (05/2021)
6.	Rice, Kenner C: 1 article (05/2021)
7.	Sulima, Agnieszka: 1 article (05/2021)
8.	Tunstall, Brendan J: 1 article (05/2021)
9.	Vendruscolo, Leandro F: 1 article (05/2021)
10.	Aubé, Jeffrey: 1 article (12/2015)

Related Diseases

1.	Infarction (Infarctions) 01/01/2012 - "Remifentanil significantly improved the functional outcome and reduced the infarct volumes (69.0±24.3 mm(3) vs. 108.9±24.8 mm(3)), which were not affected by D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH(2) or 5'-guanidinonaltrindole, but were abolished by naltrindole. "
2.	Pruritus (Itching) 12/01/2015 - "We find that the KOR antagonists nor-binaltorphimine (NorBNI) and 5'-guanidinonaltrindole (5'GNTI) induce acute pruritus in C57BL/6J mice, with reduced effects in KOR-KO mice. " 08/15/2009 - "Formalin (5%, 20 microl, s.c.) or saline was administered to the right dorsal hindpaw and the time spent licking this paw was recorded at 0-10 min and 20-35 min. For itching, mice were challenged with 5'-guanidinonaltrindole (GNTI, 0.3mg/kg, s.c., behind the neck) or saline and the number of neck-directed scratches with hindpaws was counted for 30 min. C-fos immunohistochemistry was performed in lumbar (for pain) and cervical (for scratching) spinal sections 2h after the respective treatments. "
3.	Pain (Aches) 08/15/2009 - "Formalin (5%, 20 microl, s.c.) or saline was administered to the right dorsal hindpaw and the time spent licking this paw was recorded at 0-10 min and 20-35 min. For itching, mice were challenged with 5'-guanidinonaltrindole (GNTI, 0.3mg/kg, s.c., behind the neck) or saline and the number of neck-directed scratches with hindpaws was counted for 30 min. C-fos immunohistochemistry was performed in lumbar (for pain) and cervical (for scratching) spinal sections 2h after the respective treatments. " 09/29/2009 - "administration (behind the neck) of 5'-guanidinonaltrindole (GNTI), a kappa opioid antagonist; to assess if nalfurafine prevents c-fos expression provoked by GNTI or compound 48/80, two chemically diverse pruritogens; and to distinguish on the basis of neuroanatomy, those neurons in the brainstem activated by either GNTI-induced itch or formalin-induced pain (both compounds given s.c. "
4.	Hyperalgesia 05/01/2021 - "Once hyperalgesia was established, we tested the effects of the KOR antagonists nor-binaltorphimine (norBNI; 30 mg/kg, SC) and 5'-guanidinonaltrindole (5'GNTI; 30 mg/kg, SC). " 10/01/2003 - "The administration of kappa-opioid receptor antagonists, nor-binaltorphimine (norBNI) and 5'-guanidinonaltrindole (GNTI) enhanced allodynia in rats and mice after sciatic nerve ligation. "

Related Drugs and Biologics

1.	Remifentanil (Ultiva)
2.	naltrindole
3.	norbinaltorphimine
4.	Formaldehyde (Formol)
5.	kappa Opioid Receptors (kappa Opioid Receptor)
6.	Narcotic Antagonists (Opioid Antagonists)
7.	p-Methoxy-N-methylphenethylamine
8.	TRK 820

Related Therapies and Procedures

1.	Ligation