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(meso- 1,2- bis- (2,6- dichloro- 4- hydroxyphenyl)ethylenediamine)dichloroplatinum(II)
struct'ure in first source
Also Known As:
meso-1-PtCl2
Networked:
2
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Organometallic Compounds: 64
Organoplatinum Compounds
(meso-1,2-bis-(2,6-dichloro-4-hydroxyphenyl)ethylenediamine)dichloroplatinum(II): 2
Experts
1.
Bernhardt, G
: 1 article (10/2001)
2.
Schlemmer, R
: 1 article (10/2001)
3.
Schönenberger, H
: 1 article (10/2001)
4.
Spruss, T
: 1 article (10/2001)
Related Diseases
1.
Neoplasms (Cancer)
02/01/1999 - "
These results indicate that meso-1-PtCl2 inhibits ER+ breast cancers by its estrogenicity in the same manner as meso-1 and DES.
"
10/01/2001 - "
The studies described in this publication indicate that the anti-breast cancer activity of meso-1-PtCl2 is caused by a decimation of phagocytes and with this by an abolition of the tumor promoting effect.
"
10/01/2001 - "
Meso-1-PtCl2 does not inhibit the proliferation of tumor cells by direct interaction with their DNA, as is described for platinum complexes like cDDP.
"
2.
Breast Neoplasms (Breast Cancer)
10/01/2001 - "
In its mode of action the equipotent, breast cancer inhibiting drug cDDP differs from meso-1-PtCl2.
"
02/01/1999 - "
From these results it can be concluded that there is only little if any contribution of the cytotoxic PtCl2 moiety of meso-1-PtCl2 to the anti-breast cancer activity in vivo.
"
10/01/2001 - "
The studies described in this publication indicate that the anti-breast cancer activity of meso-1-PtCl2 is caused by a decimation of phagocytes and with this by an abolition of the tumor promoting effect.
"
10/01/2001 - "
The target of meso-1-PtCl2 is the estrogen receptor (ER) of the breast cancer cell.
"
02/01/1999 - "
To clarify whether its estrogenic or its cytotoxic potency or both properties are the cause of this specific inhibitory effect, we tested meso-1-PtCl2 comparatively in vivo on an ER+ and an ER- murine breast cancer (MXT-M-3.2 MC and MXT-M-3.2(ovex) MC, respectively), and in vitro on two cell lines derived from the former in vivo models (MXT+ and MXT-, respectively).
"
Related Drugs and Biologics
1.
Estrogen Receptors
2.
Platinum
3.
DNA (Deoxyribonucleic Acid)
4.
ovex