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FKBP22

a peptidyl-prolyl cis/trans isomerase found in E coli; inhibited strongly by FK506

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bächinger, Hans Peter: 2 articles (01/2020 - 06/2014)
2.	Ishikawa, Yoshihiro: 2 articles (01/2020 - 06/2014)
3.	Belova, Vera Аlexandrovna: 1 article (01/2021)
4.	Dantsev, Ilya Sergeevich: 1 article (01/2021)
5.	Dzhivanshiryan, Goar Vladimirovna: 1 article (01/2021)
6.	Galeeva, Nailya Mansurovna: 1 article (01/2021)
7.	Kurnikova, Maria Andreevna: 1 article (01/2021)
8.	Nikolaeva, Ekaterina Alexandrovna: 1 article (01/2021)
9.	Polyakov, Alexander Vladimirovich: 1 article (01/2021)
10.	Semyachkina, Alla Nikolaevna: 1 article (01/2021)

Related Diseases

1.	Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos) 01/01/2020 - "Mutations in the FKBP14 gene encoding FKBP22 (FK506 Binding Protein 22 kDa) cause kyphoscoliotic Ehlers-Danlos Syndrome (kEDS). " 01/01/2021 - "Background. This study deals with a rare (orphan) monogenic connective tissue disorder - Ehlers-Danlos syndrome kyphoscoliotic type 2 (EDSKS2). Kyphoscoliotic type 2 Ehlers-Danlos syndrome is an autosomal recessive disorder caused by mutations in the FKBP14 gene (7p14.3), which encodes the FKBP22 protein. According to the 2017 classification, this type is in group seven - collagen spatial structure and cross-linking defects. " 06/27/2014 - "The absence of FKBP22 leads to a kyphoscoliotic type of Ehlers-Danlos syndrome (EDS), and this type of EDS is classified as EDS type VI, which can also be caused by a deficiency in lysyl-hydroxylase 1. However, the lack of FKBP22 shows a wider spectrum of clinical phenotypes than the absence of lysyl-hydroxylase 1 and additionally includes myopathy, hearing loss, and aortic rupture. " 10/13/2023 - "Mutations in the FKBP14 gene encoding the endoplasmic reticulum resident collagen-related proline isomerase FK506 binding protein 22 kDa (FKBP22) result in kyphoscoliotic Ehlers-Danlos Syndrome (EDS), which is characterized by a broad phenotypic outcome. "
2.	Hearing Loss (Hearing Impairment) 06/27/2014 - "The absence of FKBP22 leads to a kyphoscoliotic type of Ehlers-Danlos syndrome (EDS), and this type of EDS is classified as EDS type VI, which can also be caused by a deficiency in lysyl-hydroxylase 1. However, the lack of FKBP22 shows a wider spectrum of clinical phenotypes than the absence of lysyl-hydroxylase 1 and additionally includes myopathy, hearing loss, and aortic rupture. " 01/01/2020 - "The first clinical report showed that a lack of FKBP22 protein due to mutations causing nonsense-mediated decay of the mRNA leads to a wide spectrum of clinical phenotypes including progressive kyphoscoliosis, joint hypermobility, hypotonia, hyperelastic skin, hearing loss and aortic rupture. "
3.	Aortic Rupture 06/27/2014 - "The absence of FKBP22 leads to a kyphoscoliotic type of Ehlers-Danlos syndrome (EDS), and this type of EDS is classified as EDS type VI, which can also be caused by a deficiency in lysyl-hydroxylase 1. However, the lack of FKBP22 shows a wider spectrum of clinical phenotypes than the absence of lysyl-hydroxylase 1 and additionally includes myopathy, hearing loss, and aortic rupture. " 01/01/2020 - "The first clinical report showed that a lack of FKBP22 protein due to mutations causing nonsense-mediated decay of the mRNA leads to a wide spectrum of clinical phenotypes including progressive kyphoscoliosis, joint hypermobility, hypotonia, hyperelastic skin, hearing loss and aortic rupture. "
4.	Muscular Diseases (Myopathy) 06/27/2014 - "The absence of FKBP22 leads to a kyphoscoliotic type of Ehlers-Danlos syndrome (EDS), and this type of EDS is classified as EDS type VI, which can also be caused by a deficiency in lysyl-hydroxylase 1. However, the lack of FKBP22 shows a wider spectrum of clinical phenotypes than the absence of lysyl-hydroxylase 1 and additionally includes myopathy, hearing loss, and aortic rupture. "
5.	Muscle Hypotonia (Hypotonia) 01/01/2020 - "The first clinical report showed that a lack of FKBP22 protein due to mutations causing nonsense-mediated decay of the mRNA leads to a wide spectrum of clinical phenotypes including progressive kyphoscoliosis, joint hypermobility, hypotonia, hyperelastic skin, hearing loss and aortic rupture. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Collagen
3.	Tacrolimus Binding Proteins (FKBP)
4.	Peptidylprolyl Isomerase (Prolyl Isomerase)
5.	Messenger RNA (mRNA)
6.	2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine (Lysyl Hydroxylase)