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14-deoxyandrographolide

from Andrographis paniculata; structure in first source

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - 14-deoxyandrographolide: 4

Experts

1.	Jadhav, Ashwini Khanderao: 1 article (10/2021)
2.	Karuppayil, Sankunny Mohan: 1 article (10/2021)
3.	Han, Guang: 1 article (03/2020)
4.	Jia, Haiyan: 1 article (03/2020)
5.	Liu, Ling: 1 article (03/2020)
6.	Yan, Yan: 1 article (03/2020)
7.	Zheng, Lihua: 1 article (03/2020)
8.	Pholphana, Nanthanit: 1 article (05/2014)
9.	Rangkadilok, Nuchanart: 1 article (05/2014)
10.	Satayavivad, Jutamaad: 1 article (05/2014)

Related Diseases

1.	Necrosis 08/01/2010 - "Here, we evaluated the hepatoprotective efficacy of 14-deoxyandrographolide (14-DAG), a bioactive compound of AP, particularly its role in desensitization of hepatocytes to tumour necrosis factor-alpha (TNF-alpha)-induced signalling of apoptosis. " 08/01/2010 - "14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway."
2.	Neoplasms (Cancer) 05/01/2014 - "The ethanolic extract of A. paniculata at the first true leaf stage, which contained a high amount of 14-deoxyandrographolide but a low amount of andrographolide, showed a cytotoxic effect to cancer cells about 4 times higher than the water extract of A. "
3.	Human Influenza (Influenza) 10/01/2021 - "Andrographolide, neoandrographolide, dehydroandrographolide and several natural and synthetic derivatives of it: 14-deoxy-11,12-didehydroandrographolide and 14-deoxyandrographolide, dehydroandrographolide succinic acid monoester (DAMS), 14-ά-lipoyl andrographolide (AL-1), 14-acetyl-3,9-isopropyl-ideneandrographolide, 14-acetylandrographolide, 3,14,19-triacetylandrographolide, and 3,9-isopropyl-idene andrographolide, are shown to possess significant antiviral activity against HIV, influenza A, HBV, HCV, HPP and HSV. "
4.	Inflammation (Inflammations) 03/01/2020 - "Isoandrographolide and 14-deoxyandrographolide are potent inhibitor of inflammation.[Formula: see text]."
5.	Bile Duct Neoplasms (Bile Duct Cancer) 05/01/2014 - "Andrographolide, not 14-deoxy-11,12-didehydroandrographolide, neoandrographolide, or 14-deoxyandrographolide, possessed potent cytotoxic activity against the growth of liver and bile duct cancer cells. "

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	andrographolide
3.	14-deoxy-11,12-didehydroandrographolide
4.	neoandrographolide
5.	Succinic Acid (Succinate)
6.	Calcium
7.	Antiviral Agents (Antivirals)
8.	dehydroandrographolide
9.	N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))