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LU 25-109-T
partial muscarinic M1 agonist and presynaptic M2 autoreceptor antagonist
Also Known As:
5-(2-ethyl-2H-tetrazol-5-yl)-1,2,3,6-tetrahydro-1-methylpyridine tartrate; LU 25-109; LU-25-109-T
Networked:
7
relevant articles (
2
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Tetrazoles: 14
LU 25-109-T: 7
Pyridines: 88
LU 25-109-T: 7
Experts
1.
Forrest, M
: 1 article (01/2000)
2.
Loft, H
: 1 article (01/2000)
3.
Mengel, H
: 1 article (01/2000)
4.
Thal, L J
: 1 article (01/2000)
Related Diseases
1.
Alzheimer Disease (Alzheimer's Disease)
01/01/1998 - "
This double-blind, placebo-controlled, two-part, inpatient bridging study was designed to evaluate the safety and tolerability of multiple oral doses of Lu 25-109 in patients with Alzheimer's Disease(AD), and to determine the maximum tolerated dose (MTD) in this population.
"
01/01/1998 - "
A bridging study of LU 25-109 in patients with probable Alzheimer's disease.
"
06/01/1998 - "
Lu 25-109 [5-(2-ethyl-2H-tetrazol-5-yl)-1,2,3,6-tetrahydro-1-methylpyridine] , has M agonistic and M2/M3 antagonistic effects at muscarinic receptors in vitro; a pharmacological profile that may be beneficial in treatment of Alzheimer's disease.
"
01/25/2000 - "
Lu 25-109, a muscarinic agonist, fails to improve cognition in Alzheimer's disease.
"
01/01/1999 - "
Biotransformation of the M1-muscarinic agonist Lu 25-109 (5-(2-ethyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetrahydropyridine) , in development for the treatment of Alzheimer's disease, was investigated to obtain information on the identity of human hepatic cytochrome P-450 enzymes involved in its metabolism.
"
2.
Traumatic Brain Injuries (Traumatic Brain Injury)
09/01/1997 - "
Lu 25-109-T is a partial muscarinic M1 receptor agonist with antagonistic effects at presynaptic M2 autoreceptors and has been shown to improve cognitive function following traumatic brain injury (TBI) in rats.
"
3.
Amyloid Plaque
01/01/1998 - "
In as much as stimulation of APPs secretion is associated with reduced formation of A beta peptides, Lu 25-109 may be useful to reduce A beta generation, and thus, slow amyloid plaque formation.
"
4.
Tremor (Tremors)
06/01/1998 - "
Lu 25-109 did not antagonize oxotremorine-induced hypothermia, tremor and salivation in mice and antagonized physostigmine-induced lethality with low potency.
"
06/01/1998 - "
Unlike non-selective muscarinic agonists and acetylcholinesterase inhibitors, Lu 25-109 did not induce hypothermia, tremor or salivation in mice.
"
5.
Hypothermia
06/01/1998 - "
Unlike non-selective muscarinic agonists and acetylcholinesterase inhibitors, Lu 25-109 did not induce hypothermia, tremor or salivation in mice.
"
Related Drugs and Biologics
1.
Muscarinic M1 Receptor
2.
Autoreceptors
3.
Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
4.
Muscarinic Agonists
5.
Proteins (Proteins, Gene)
6.
Physostigmine
7.
Peptides (Polypeptides)
8.
Oxotremorine
9.
Cytochrome P-450 Enzyme System (Cytochrome P450)
10.
Cholinesterase Inhibitors (Anticholinesterases)
Related Therapies and Procedures
1.
Induced Hypothermia