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NNC 05-2090

structure given in first source

Also Known As:

1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - NNC 05-2090: 2

Experts

1.	Hiramatsu, Masayuki: 1 article (01/2019)
2.	Ibi, Daisuke: 1 article (01/2019)
3.	Nomura, Tomohiro: 1 article (01/2019)
4.	Tsuchihashi, Azumi: 1 article (01/2019)

Related Diseases

1.	Cognitive Dysfunction 01/05/2019 - "Of note, NNC 05-2090, a selective inhibitor of betaine/GABA transporter-1 (GAT2/BGT-1), reduced the preventive effects of betaine on Aβ25-35-induced cognitive impairment without affecting the increased MDA levels in the brain of Aβ25-35-injected mice. "
2.	Seizures (Absence Seizure) 07/01/1997 - "In amygdala kindled rats NNC 05-2045 and NNC 05-2090 significantly (P < 0.05) reduced generalized seizure severity (seizure grade 3-5) at highest doses (72-242 mumol/kg) and NNC 05-2090 also significantly reduced afterdischarge duration at these doses (P < 0.05). " 07/01/1997 - "NNC 05-2045 also antagonized sound-induced seizures in genetic epilepsy prone rats (GEP rats) with ED50 values against wild running, clonic and tonic convulsions of 33, 39 and 39 mumol/kg, respectively (NNC 05-2090 was not tested in GEP rats). "
3.	Epilepsy (Aura) 07/01/1997 - "NNC 05-2045 also antagonized sound-induced seizures in genetic epilepsy prone rats (GEP rats) with ED50 values against wild running, clonic and tonic convulsions of 33, 39 and 39 mumol/kg, respectively (NNC 05-2090 was not tested in GEP rats). "

Related Drugs and Biologics

1.	gamma-Aminobutyric Acid (GABA)
2.	Betaine (C.B.B.)
3.	NNC 05-2045