broussochalcone A

RN given for (E)-isomer; inhibits neutrophil respiratory burst; structure in first source

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

1.	Pancreatic Neoplasms (Pancreatic Cancer) 04/16/2021 - "In this study, we identified broussochalcone A (BCA) as a new NR4A1 inhibitor and demonstrated that BCA inhibits cell growth partly by inducing NR4A1-mediated apoptotic pathways in human pancreatic cancer cells. " 04/16/2021 - "Broussochalcone A Is a Novel Inhibitor of the Orphan Nuclear Receptor NR4A1 and Induces Apoptosis in Pancreatic Cancer Cells."
2.	Neoplasms (Cancer) 03/15/2018 - "The inhibitory potential of Broussochalcone A for the human cytochrome P450 2J2 isoform and its anti-cancer effects via FOXO3 activation."
3.	Liver Neoplasms (Liver Cancer) 09/01/2019 - "Cytotoxic activity of broussochalcone a against colon and liver cancer cells by promoting destruction complex-independent β-catenin degradation."
4.	Kidney Neoplasms (Kidney Cancer) 01/01/2021 - "Broussochalcone A Induces Apoptosis in Human Renal Cancer Cells via ROS Level Elevation and Activation of FOXO3 Signaling Pathway."

1.	Member 1 Group A Nuclear Receptor Subfamily 4
2.	Catenins
3.	Protein Isoforms (Isoforms)
4.	Cytochrome P-450 Enzyme System (Cytochrome P450)