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harmol sulfate

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ho, Qin Shi: 1 article (01/2016)
2.	Lim, Hwee Ying: 1 article (01/2016)
3.	Wong, Kim Ping: 1 article (01/2016)
4.	Brouwer, Kim L R: 1 article (11/2008)
5.	Hoffmaster, Keith A: 1 article (11/2008)
6.	Nezasa, Ken-ichi: 1 article (11/2008)
7.	Zamek-Gliszczynski, Maciej J: 1 article (11/2008)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 11/01/2008 - "Previous experiments demonstrated that the biliary excretion of harmol sulfate (HS) was mediated by breast cancer resistance protein (Bcrp) and not by multidrug resistance-associated protein (Mrp)2 or P-glycoprotein in mice. " 01/01/2016 - "3. Using Ko-143, a specific inhibitor of breast cancer resistance protein (BCRP), an ATP-binding cassette (ABC) transporter, we identified this transporter to be responsible for the efflux of p-cresol sulfate, harmol sulfate and the glutathione conjugate of 1-chloro-2,4-dinitrobenzene. "
2.	Cholestasis 06/01/1982 - "Prevention of harmol-induced cholestasis by increased formation of harmol sulfate." 06/01/1982 - "Intravenous infusion of harmol (250 mumol/hr/kg b.wt.) in vivo in the rat considerably decreased the availability of sulfate and, consequently, the amount of harmol sulfate excreted in bile and urine; this decrease was compensated for by an increase in glucuronidation, which caused complete cholestasis when the concentration of harmol glucuronide in bile became of the order of 20 mM. A sufficient supply of sulfate by infusion of sodium sulfate prevented the decrease in sulfation and the increase in glucuronidation and no cholestasis occurred. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Multidrug Resistance-Associated Proteins
3.	Member 1 Subfamily B ATP Binding Cassette Transporter
4.	ATP-Binding Cassette Transporters (ABC Transporters)
5.	Sulfates (Sulfates, Inorganic)
6.	Glutathione (Reduced Glutathione)
7.	Dinitrochlorobenzene (DNCB)
8.	Adenosine Triphosphate (ATP)
9.	3- (6- isobutyl- 9- methoxy- 1,4- dioxo- 1,2,3,4,6,7,12,12a- octahydropyrazino(1',2'- 1,6)pyrido(3,4- b)indol- 3- yl)propionic acid tert-butyl ester
10.	4-cresol sulfate

Related Therapies and Procedures

1.	Intravenous Infusions