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6- (trifluoroacetamido)- 4,5- dihydroxypiperidine- 3- carboxylic acid

a heparanase inhibitor with antineoplastic activity; RN given for (3S-(3alpha,4alpha,5alpha,6beta))-isomer; structure in first source

Also Known As:

6-TFA-4,5-DHPC; heparastatin

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - Nipecotic Acids
      - 6-(trifluoroacetamido)-4,5-dihydroxypiperidine-3-carboxylic acid: 1
- Heterocyclic Acids
  - Nipecotic Acids
    - 6-(trifluoroacetamido)-4,5-dihydroxypiperidine-3-carboxylic acid: 1
Organic Chemicals: 133
- Imines: 310
  - Imino Sugars: 24
    - 6-(trifluoroacetamido)-4,5-dihydroxypiperidine-3-carboxylic acid: 1
Carbohydrates: 22023
- Imino Sugars: 24
  - 6-(trifluoroacetamido)-4,5-dihydroxypiperidine-3-carboxylic acid: 1

Experts

1.	Adachi, Hayamitsu: 1 article (06/2016)
2.	Higashi, Nobuaki: 1 article (06/2016)
3.	Irimura, Tatsuro: 1 article (06/2016)
4.	Kepka, Magdalena: 1 article (06/2016)
5.	Kogane, Yusuke: 1 article (06/2016)
6.	Kolaczkowska, Elzbieta: 1 article (06/2016)
7.	Nakajima, Motowo: 1 article (06/2016)
8.	Nishimura, Yoshio: 1 article (06/2016)
9.	Shida, Hiroaki: 1 article (06/2016)
10.	Sue, Mayumi: 1 article (06/2016)

Related Diseases

1.

Inflammation (Inflammations)

06/01/2016 - "Taken together, in a dorsal air pouch inflammation model heparastatin (SF4) potentially suppresses extravasation of inflammatory cells by impairing the degradation of basement membrane heparan sulfate. "
06/01/2016 - "In the present study, we examined whether administration of heparastatin (SF4), an iminosugar-based inhibitor of heparanase, could suppress local inflammation and degradation of heparan sulfate proteoglycans in basement membranes. "
06/01/2016 - "In a carrageenan- or formyl peptide-induced dorsal air pouch inflammation model, the number of infiltrated neutrophils and monocytes was significantly lower in mice after topical administration of heparastatin (SF4). "

Related Drugs and Biologics

1.	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)
2.	sulfur tetrafluoride
3.	heparanase
4.	Peptides (Polypeptides)
5.	Heparitin Sulfate (Heparan Sulfate)
6.	Carrageenan

Related Therapies and Procedures

1.	Topical Administration