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6-chlorotacrine

structure given in first source

Also Known As:

6-Cl-tacrine

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Acridines: 325
      - Aminoacridines: 3
        Tacrine: 772
        6-chlorotacrine: 5

Experts

1.	Bartolini, Manuela: 2 articles (01/2022 - 03/2018)
2.	Muñoz-Torrero, Diego: 2 articles (01/2022 - 03/2018)
3.	Pérez, Belén: 2 articles (01/2022 - 03/2018)
4.	Korabecny, Jan: 2 articles (01/2019 - 01/2018)
5.	Nepovimova, Eugenie: 2 articles (01/2019 - 01/2018)
6.	Soukup, Ondrej: 2 articles (01/2019 - 01/2018)
7.	Bartra, Clara: 1 article (01/2022)
8.	Brea, José: 1 article (01/2022)
9.	Calvó-Tusell, Carla: 1 article (01/2022)
10.	Codony, Sandra: 1 article (01/2022)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 01/01/2018 - "Observed effects predetermined 6-chlorotacrine as a potent parent compound for the synthesis of novel multifactorial drugs intended to the treatment of Alzheimer's disease. " 01/01/2019 - "Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease."
2.	Poisoning 01/01/2017 - "In addition, the highest dose of 6-chlorotacrine was significantly more effective to protect mice from soman poisoning than its lowest dose. "
3.	Myasthenia Gravis 03/11/2018 - "Here, we have explored two alternative approaches to get access to peripherally-acting AChE inhibitors as new agents against myasthenia gravis, by structural modification of the brain permeable anti-Alzheimer AChE inhibitors tacrine, 6-chlorotacrine, and huprine Y. "
4.	Amnesia (Dissociative Amnesia) 01/01/2018 - "6-chlorotacrine showed good effects in the reversal of quinuclidinyl benzilate-induced amnesia. "
5.	Neuroinflammatory Diseases 01/01/2022 - "Here, we disclose a class of 6-chlorotacrine (huprine)-TPPU hybrids as dual inhibitors of the enzymes soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE), a multitarget profile to provide cumulative effects against neuroinflammation and memory impairment. "

Related Drugs and Biologics

1.	Tacrine (Cognex)
2.	Soman
3.	Quinuclidinyl Benzilate
4.	Memantine (Namenda)
5.	Epoxide Hydrolases
6.	Enzymes
7.	Acetylcholinesterase
8.	huprine Y