5,8- dihydroxy- 3- methyl- 4- (9H)- naphtho(2,3- c)furanone

12/01/2022 - "In conclusion, this study provides clinical guidance for maintaining fertility during the treatment of cancer with MS-444 in women of reproductive age. "
12/01/2022 - "The HuR small-molecule inhibitor MS-444 has been used in many cancer treatment studies, but its reproductive toxicity in females is unknown. "
01/01/2021 - "Ectopic HuR accelerates allograft tumor progression in vivo, which is greatly compromised by simultaneous administration with MS-444. "
01/01/2019 - "At the molecular level, MS-444 treatment led to an attenuation of mRNAs in different tumor promoting pathways including angiogenesis, immune evasion and suppression of apoptosis. "
11/08/2016 - "In vivo treatment of MS-444 inhibited HuR cytoplasmic localization and decreased COX-2 expression in tumors. "

11/08/2016 - "Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis."

01/01/2017 - "Intraperitoneal injection of the HuR small-molecule inhibitor MS-444 in AOM/DSS mice, a model of IBD and inflammatory colon cancer, augmented DSS-induced weight loss and increased tumor multiplicity, size, and invasiveness. "

11/08/2016 - "Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis."

01/01/2016 - "Although the HuR inhibitor MS-444 significantly impaired migration in both melanoma cell lines, it reduced WNT5A expression only in HTB63 cells, as did small interfering RNA knockdown of HuR. "