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SCH 51048

Also Known As:

SCH-51048

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - SCH 51048: 3

Related Diseases

1.	Infections 03/01/1995 - "We tested the in vivo efficacy of SCH 51048, an investigational antifungal triazole, in experimental hematogenous murine infection caused by two C. " 03/01/1995 - "Our results indicate that SCH 51048 is the first triazole that has in vivo activity against experimental infection with C. " 03/01/1995 - "SCH 51048, a new antifungal triazole active against hematogenous Candida krusei infections in neutropenic mice."
2.	Body Weight (Weight, Body) 03/01/1995 - "Treatment with SCH 51048 (50 or 100 mg/kg of body weight per day orally) or amphotericin B (2 mg/kg/day intraperitoneally) significantly prolonged the survival of infected mice and significantly reduced fungal titers in the kidneys (P < or = 0.05). " 05/01/1995 - "immitis in vitro; MICs for 13 isolates ranged from < or = 0.39 to 0.78 micrograms/ml, and minimum fungicidal concentrations ranged from < or = 0.39 to 1.6 micrograms/ml. In vivo, no mice treated with SCH 51048 at 2 to 50 mg/kg of body weight or 100 mg of fluconazole or itraconazole per kg died of systemic coccidioidomycosis, whereas 60 to 100% of the control mice died. "
3.	Coccidioidomycosis 05/01/1995 - "immitis in vitro; MICs for 13 isolates ranged from < or = 0.39 to 0.78 micrograms/ml, and minimum fungicidal concentrations ranged from < or = 0.39 to 1.6 micrograms/ml. In vivo, no mice treated with SCH 51048 at 2 to 50 mg/kg of body weight or 100 mg of fluconazole or itraconazole per kg died of systemic coccidioidomycosis, whereas 60 to 100% of the control mice died. "
4.	Blastomycosis 04/01/1995 - "On the basis of these experiments, clinical evaluation of SCH 51048 for the use in treatment of human blastomycosis should proceed." 04/01/1995 - "In a well-described murine model of acute pulmonary blastomycosis, SCH 51048 was comparable to amphotericin B and at least 30 times more active than itraconazole. " 04/01/1995 - "Treatment of murine pulmonary blastomycosis with SCH 51048, a broad-spectrum triazole antifungal agent."

Related Drugs and Biologics

1.	Triazoles
2.	Itraconazole (Sporanox)
3.	Amphotericin B (Amphotericin)
4.	Fluconazole (Zonal)
5.	Antifungal Agents