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leminoprazole
Also Known As:
(+-)-2-((2-(isobutylmethylamino)benzyl)sulfinyl)-1H-benzimidazole; NC 1300-O-3; NC-1300-O-3
Networked:
6
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzimidazoles: 245
leminoprazole: 6
Related Diseases
1.
Ulcer
05/01/1993 - "
Therefore, NC-1300-O-3 seems to promote ulcer healing or prevents delayed healing by its potential antisecretory and/or ulcer-healing activities.
"
05/01/1993 - "
A bolus administration of NC-1300-O-3 to rats with 5-day-old ulcers potently and persistently (> 48 hr) inhibited both the basal and histamine-stimulated gastric secretion.
"
05/01/1993 - "
The delay in ulcer healing caused by indomethacin was markedly prevented by concurrent administration of NC-1300-O-3 once daily for 4 weeks in a dose-related manner.
"
05/01/1993 - "
NC-1300-O-3, administered orally once daily for 2, 4 or 8 weeks after ulceration, significantly accelerated the spontaneous healing of both fresh and unhealed ulcers (induced by pretreatment with indomethacin).
"
11/01/1998 - "
Both omeprazole and leminoprazole significantly enhanced ulcer healing and inhibited the clarithromycin-delayed ulcer healing.
"
2.
Stomach Ulcer (Gastric Ulcer)
05/01/1993 - "
We examined the effect of NC-1300-O-3 on the healing of acetic acid-induced gastric ulcers in male Donryu rats.
"
05/01/1993 - "
Effect of NC-1300-O-3 on healing of acetic acid-induced gastric ulcers in rats.
"
11/01/1998 - "
Effects of clarithromycin, omeprazole and leminoprazole on gastric ulcer healing in Helicobacter pylori-infected rats.
"
05/01/1993 - "
Administration of the compound together with indomethacin for 8 weeks resulted in a significant increase in the volume, no change in acid output and a significant increase in the pH. The spontaneous or delayed healing of gastric ulcers induced 4 weeks after pretreatment with NC-1300-O-3 was also significantly enhanced or prevented with NC-1300-O-3, with a weakened antisecretory activity.
"
04/01/1996 - "
Effects of leminoprazole, omeprazole and sucralfate on indomethacin-induced delayed healing of kissing gastric ulcers in rats.
"
3.
Spontaneous Remission
05/01/1993 - "
NC-1300-O-3, administered orally once daily for 2, 4 or 8 weeks after ulceration, significantly accelerated the spontaneous healing of both fresh and unhealed ulcers (induced by pretreatment with indomethacin).
"
4.
Peptic Ulcer (Peptic Ulcers)
07/01/1994 - "
The effect of leminoprazole on gastric mucus secretion might contribute to healing the peptic ulcer diseases and may be involved in the cytoprotective mechanism of this drug.
"
5.
Peptic Esophagitis (Reflux Esophagitis)
12/01/1995 - "
Mucosal protective effect of leminoprazole on reflux esophagitis induced in rats.
"
12/01/1995 - "
We examined the effect of leminoprazole (an acid pump inhibitor) on reflux esophagitis induced in rats.
"
Related Drugs and Biologics
1.
Omeprazole (Prilosec)
2.
Indomethacin (Indometacin)
3.
Acids
4.
Acetic Acid (Vinegar)
5.
Clarithromycin (Biaxin)
6.
Sucralfate (Carafate)
7.
Peroxidase (Myeloperoxidase)
8.
Histamine (Histamine Dihydrochloride)
9.
Cimetidine (Biomet)