HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

Ro 32-0432

Also Known As:

(S)-3-(8-(dimethylaminomethyl)-6,7,8,9-tetrahydropyrido(1,2-a)indol-10-yl)-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione hydrochloride; Ro-32-0432

Networked: 12 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - Ro 32-0432: 12
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Ro 32-0432: 12

Experts

1.	Qi, Zhi: 2 articles (01/2022 - 08/2017)
2.	Zhong, Chunlian: 2 articles (01/2022 - 08/2017)
3.	Molkentin, Jeffery D: 2 articles (12/2011 - 08/2006)
4.	Jia, Lee: 1 article (01/2022)
5.	Li, Yumei: 1 article (01/2022)
6.	Lu, Yusheng: 1 article (01/2022)
7.	Xie, Xinwen: 1 article (01/2022)
8.	Zhang, Jinwei: 1 article (01/2022)
9.	Zhao, Huan: 1 article (01/2022)
10.	Chang, He: 1 article (08/2017)

Related Diseases

1.	Edema (Dropsy) 02/01/1994 - "Oral administration of Ro 32-0432 inhibited subsequent phorbol ester-induced edema in rats demonstrating the systemic efficacy of the compound to inhibit PKC-driven responses. "
2.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/09/2007 - "The present study aimed to examine the effect of the PKC inhibitor Ro-32-0432 on endothelin receptor upregulation, infarct volume and neurology outcome after middle cerebral artery occlusion in rat. "
3.	Tobacco Use Disorder (Nicotine Dependence) 03/01/2013 - "It is concluded that Ro 32-0432 attenuates the propagation of nicotine dependence and reduce withdrawal signs possibly by G protein-coupled receptor kinase 5 activation-linked mechanisms." 03/01/2013 - "Therefore, the present study investigated the effect of Ro 32-0432, a G protein-coupled receptor kinase 5 inhibitor, on propagation of nicotine dependence and resultant withdrawal signs in subchronic nicotine mouse model. "
4.	Infarction (Infarctions) 01/09/2007 - "The present study aimed to examine the effect of the PKC inhibitor Ro-32-0432 on endothelin receptor upregulation, infarct volume and neurology outcome after middle cerebral artery occlusion in rat. " 01/09/2007 - "The results suggest that treatment with Ro-32-0432 in ischemic stroke decreases the ischemic infarction area, neurological symptoms and associated endothelin B receptor upregulation. "
5.	Pain (Aches) 01/01/2004 - "administration of RO-32-0432 reversed a long-lasting pain-like syndrome as indicated by thermal hyperalgesia following sciatic nerve ligation in mice. " 01/01/2014 - "pretreatment with the protein kinase Cα (PKCα) inhibitor Ro-32-0432 completely restored the reduced morphine antinociception in the contralateral paw but only partially restored it in the ipsilateral paw in the inflammatory pain state. "

Related Drugs and Biologics

1.	Phorbol Esters
2.	G-Protein-Coupled Receptor Kinase 5
3.	Endothelin Receptors (Endothelin Receptor)
4.	Nicotine
5.	Protein Kinases (Protein Kinase)
6.	rho-Associated Kinases
7.	Endothelin B Receptor
8.	Small Interfering RNA (siRNA)
9.	Interleukin-17 (Interleukin 17)
10.	Connexin 43 (Connexin43)

Related Therapies and Procedures

1.	Oral Administration
2.	Ligation