dipsacoside B

from flowers of Lonicera macranthoides Hand

Also Known As:

3-O-alpha-L-rhamnopyranosyl (1-->2)-alpha-L-arabinopyranosyl hederagenin 28-O-beta-D-glucopyranosyl (1-->6)-beta-D-glucopyranosyl ester

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - Pentacyclic Triterpenes: 108
        Oleanolic Acid: 547
        dipsacoside B: 1
      - Sapogenins: 26
        Oleanolic Acid: 547
        dipsacoside B: 1
Carbohydrates: 22023
- Glycosides: 2119
  - Saponins: 2867
    - dipsacoside B: 1

Experts

1.	Hu, Zhong-Yang: 1 article (01/2022)
2.	Luo, Xiu-Ju: 1 article (01/2022)
3.	Peng, Jun: 1 article (01/2022)
4.	Peng, Ya-Wei: 1 article (01/2022)
5.	Peng, Zi-Mei: 1 article (01/2022)
6.	Ren, Kai-Di: 1 article (01/2022)
7.	Tian, Jing: 1 article (01/2022)
8.	Zhang, Xiao-Jie: 1 article (01/2022)
9.	Zhang, Yi-Yue: 1 article (01/2022)

Related Diseases

1.	Brain Injuries (Brain Injury) 01/01/2022 - "The aim of the study was to explore whether Dipsacoside B can exert a beneficial effect on brain injury in the ischemic stroke rat via targeting Mul1. " 01/01/2022 - "Upregulation of mitochondrial E3 ubiquitin ligase 1 (Mul1) contributes to brain injury in ischemic stroke due to disturbance of mitochondrial dynamics, and bioinformatics analysis predicts that Mul1 is a potential target of Dipsacoside B. " 01/01/2022 - "Dipsacoside B Exerts a Beneficial Effect on Brain Injury in the Ischemic Stroke Rat through Inhibition of Mitochondrial E3 Ubiquitin Ligase 1."
2.	Ischemic Stroke 01/01/2022 - "The aim of the study was to explore whether Dipsacoside B can exert a beneficial effect on brain injury in the ischemic stroke rat via targeting Mul1. " 01/01/2022 - "The SD rat brains or PC12 cells were subjected to 2 h-ischemia or 8 h-hypoxia plus 24 h-reperfusion or 24 h-reoxygenation to establish the ischemic stroke rat model in vivo or in vitro, which were treated with Dipsacoside B at different dosages. " 01/01/2022 - "Upregulation of mitochondrial E3 ubiquitin ligase 1 (Mul1) contributes to brain injury in ischemic stroke due to disturbance of mitochondrial dynamics, and bioinformatics analysis predicts that Mul1 is a potential target of Dipsacoside B. " 01/01/2022 - "Dipsacoside B Exerts a Beneficial Effect on Brain Injury in the Ischemic Stroke Rat through Inhibition of Mitochondrial E3 Ubiquitin Ligase 1."
3.	Ischemia 01/01/2022 - "The SD rat brains or PC12 cells were subjected to 2 h-ischemia or 8 h-hypoxia plus 24 h-reperfusion or 24 h-reoxygenation to establish the ischemic stroke rat model in vivo or in vitro, which were treated with Dipsacoside B at different dosages. "
4.	Hypoxia (Hypoxemia) 01/01/2022 - "The SD rat brains or PC12 cells were subjected to 2 h-ischemia or 8 h-hypoxia plus 24 h-reperfusion or 24 h-reoxygenation to establish the ischemic stroke rat model in vivo or in vitro, which were treated with Dipsacoside B at different dosages. " 01/01/2022 - "Consistently, cell injury (necroptosis and apoptosis) occurred in the PC12 cells exposed to hypoxia concomitant with the upregulation of Mul1 and Drp1 along with downregulation of Mfn2 and mitochondrial functions (such as increases in reactive oxygen species production and mitochondrial fission and decreases in mitochondrial membrane potential and ATP production).These phenomena were reversed in the presence of Dipsacoside B. "

Related Drugs and Biologics

1.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
2.	Reactive Oxygen Species (Oxygen Radicals)
3.	Adenosine Triphosphate (ATP)