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L 158338
structure given in first source; angiotensin receptor antagonist
Also Known As:
3H-Imidazo(4,5-b)pyridine, 7-methyl-2-propyl-3-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-; 7-methyl-2-propyl-3-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-3H-imidazo(4,5-b)pyridine; L 158,338; L-158,338; L-158338
Networked:
2
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Imidazoles: 150
L 158338: 2
Pyridines: 88
L 158338: 2
Related Diseases
1.
Ischemia
10/01/1994 - "
Significantly milder acidosis during ischemia and significantly increased coronary flow were characteristic of the improved functional recovery exhibited by the groups treated with either lisinopril or L-158,338 in vivo.
"
10/01/1994 - "
To assess the role of angiotensin II (AII) in development of myocardial injury during ischemia and reperfusion, the effects of short-term treatment with the angiotensin-converting enzyme (ACE) inhibitor lisinopril were compared with the effects of short-term treatment with L-158,338, an AII antagonist, in isolated working rat heart.
"
2.
Acidosis
10/01/1994 - "
Significantly milder acidosis during ischemia and significantly increased coronary flow were characteristic of the improved functional recovery exhibited by the groups treated with either lisinopril or L-158,338 in vivo.
"
3.
Hypertrophy
10/01/1994 - "
Juxtaglomerular (JG) cell hypertrophy and hyperplasia were investigated in rhesus monkeys given angiotensin II (AII) AT1 receptor antagonists L-158,338 and DUP 753 (MK-0954, losartan).
"
10/01/1994 - "
To investigate the observed JG hypertrophy and hyperplasia, in a third 5-week experiment L-158,338 was given alone at 90 mg/kg/day, or with physiologic saline supplementation at 25 ml/kg/day, or coadministered with the angiotensin converting enzyme inhibitor enalapril at 10 mg/kg/day.
"
4.
Hyperplasia
10/01/1994 - "
Juxtaglomerular (JG) cell hypertrophy and hyperplasia were investigated in rhesus monkeys given angiotensin II (AII) AT1 receptor antagonists L-158,338 and DUP 753 (MK-0954, losartan).
"
10/01/1994 - "
To investigate the observed JG hypertrophy and hyperplasia, in a third 5-week experiment L-158,338 was given alone at 90 mg/kg/day, or with physiologic saline supplementation at 25 ml/kg/day, or coadministered with the angiotensin converting enzyme inhibitor enalapril at 10 mg/kg/day.
"
Related Drugs and Biologics
1.
Lisinopril (Prinivil)
2.
Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
3.
Angiotensin II
4.
Losartan (Cozaar)
5.
Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
6.
Enalapril
7.
Dihydrotachysterol (AT 10)