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lumidoxycycline
a doxycycline (DOTC) photoproduct; phototoxic; has greater photostability compared to DOTC; structure given in first source
Also Known As:
LuDOTC
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Naphthacenes
Tetracyclines: 1162
Doxycycline: 5919
lumidoxycycline: 1
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Naphthacenes
Tetracyclines: 1162
Doxycycline: 5919
lumidoxycycline: 1
Related Diseases
1.
Phototoxic Dermatitis (Phototoxicity)
09/01/1993 - "
Phototoxicity of lumidoxycycline.
"
09/01/1993 - "
These data demonstrate that DOTC photo-products such as LuDOTC have significant photobiologic activity and may play an important role in the phototoxicity mechanism of DOTC.
"
09/01/1993 - "
For both DOTC and LuDOTC, phototoxicity was increased by irradiation in the presence of deuterium oxide and decreased in the presence of sodium azide, effects consistent with an important mechanistic role for singlet oxygen, O2(1 delta g), in the injury.
"
2.
Photosensitivity Disorders (Photodermatitis)
09/01/1993 - "
Epifluorescence microscopy of cells labeled with the mitochondrial probe, rhodamine 123, showed mitochondrial fragmentation and altered mitochondrial membrane integrity after LuDOTC photosensitization; these effects depended on radiant exposure and were partially reversible by 24 h after irradiation.
"
09/01/1993 - "
To assess the role of a DOTC photoproduct, lumidoxycycline (LuDOTC), in the photosensitization mechanism of DOTC, MGH-U1 human bladder carcinoma cells were treated in vitro with either DOTC or LuDOTC, and irradiated with the 351-nm emission of an argon-ion laser.
"
3.
Carcinoma (Carcinomatosis)
09/01/1993 - "
To assess the role of a DOTC photoproduct, lumidoxycycline (LuDOTC), in the photosensitization mechanism of DOTC, MGH-U1 human bladder carcinoma cells were treated in vitro with either DOTC or LuDOTC, and irradiated with the 351-nm emission of an argon-ion laser.
"
Related Drugs and Biologics
1.
lumidoxycycline
2.
Singlet Oxygen
3.
Rhodamine 123
4.
Sodium Azide
5.
Deuterium Oxide (Heavy Water)
6.
2'-deoxy-3'-oxa-thiocytidine (DOTC)
Related Therapies and Procedures
1.
Gas Lasers