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F 721
RN given refers to the hydrochloride salt
Also Known As:
3-diethylamino-2,2-dimethylpropyl 5-(4-trifluoromethylphenyl)-2-furoate; F-721
Networked:
1
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Furans: 85
F 721: 1
Related Diseases
1.
Seizures (Absence Seizure)
05/01/1993 - "
F-721 was also effective against corneal-kindled and amygdaloid-kindled seizures in rats.
"
05/01/1993 - "
F-721 suppressed stage 5 seizures in corneal-kindled rats with an ED50 of 15 mg/kg, ip.
"
05/01/1993 - "
The profile of anticonvulsant activity of F-721 suggests potential utility in the management of generalized tonic-clonic, simple and complex partial seizures.
"
05/01/1993 - "
However, F-721 was notably more efficacious in suppressing amygdaloid-kindled seizures in rats and was a more potent antagonist of icv NMDA clonic seizures.
"
05/01/1993 - "
F-721 was effective against MES seizures following oral administration to mice (ED50: 31.3 mg/kg) and only partially effective by this route against clonic seizures induced by subcutaneous Metrazol.
"
Related Drugs and Biologics
1.
Quisqualic Acid
2.
N-Methylaspartate (NMDA)
3.
Picrotoxin
4.
Pentylenetetrazole (Metrazol)
5.
Strychnine
6.
Bicuculline
7.
Anticonvulsants (Antiepileptic Drugs)
Related Therapies and Procedures
1.
Oral Administration